TY - JOUR
T1 - Treatment of intracranial aneurysms with self-expandable braided stents
T2 - A systematic review and meta-analysis
AU - Cagnazzo, F.
AU - Cappucci, M.
AU - Lefevre, P. H.
AU - Dargazanli, C.
AU - Gascou, G.
AU - Morganti, R.
AU - Mazzotti, V.
AU - Di Carlo, D.
AU - Perrini, P.
AU - Mantilla, D.
AU - Riquelme, C.
AU - Bonafe, A.
AU - Costalat, V.
N1 - Publisher Copyright:
© 2018 by the American Society of Neuroradiology.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - BACKGROUND: The safety and efficacy of treatment with self-expandable braided stents (LEO and LVIS) required further investigation. PURPOSE: Our aim was to analyze the outcomes after treatment with braided stents. DATA SOURCES: A systematic search of 3 databases was performed for studies published from 2006 to 2017. STUDY SELECTION: According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we included studies reporting patients treated with LEO or LVIS stents. DATA ANALYSIS: Random-effects meta-analysis was used to pool the following: aneurysm occlusion rate, complications, and neurologic outcomes. DATA SYNTHESIS: Thirty-five studies evaluating 1426 patients treated with braided stents were included in this meta-analysis. Successful stent delivery and complete aneurysm occlusion were 97% (1041/1095; 95% CI, 95%-98%) (I2=44%) and 88.3% (1097/1256; 95% CI, 85%-91%) (I2= 72%), respectively. Overall, treatment-related complications were 7.4% (107/1317; 95% CI, 5%-9%) (I2= 44%). Ischemic/thromboembolic events (48/1324=2.4%; 95% CI, 1.5%-3.4%) (I2=27%) and in-stent thrombosis (35/1324=1.5%; 95% CI, 0.6%-1.7%) (I2=0%) were the most common complications. Treatment-related morbidity was 1.5% (30/1324; 95% CI, 0.9%-2%) and was comparable between the LEO and LVIS groups. Complication rates between the anterior (29/322 = 8.8%; 95% CI, 3.4%-12%) (I2= 41%) versus posterior circulation (10/84 = 10.5%; 95% CI, 4%-16%) (I2= 0%) and distal (30/303 = 8%; 95% CI, 4.5%-12%) (I2= 48%) versus proximal aneurysms (14/153 = 9%; 95% CI, 3%-13%) (I2= 46%) were comparable (P > .05). LIMITATIONS: Limitations were selection and publication biases. CONCLUSIONS: In this analysis, treatment with the LEO and LVIS stents was relatively safe and effective. The most common complications were periprocedural thromboembolisms and in-stent thrombosis. The rate of complications was comparable among anterior and posterior circulation aneurysms, as well as for proximal and distally located lesions.
AB - BACKGROUND: The safety and efficacy of treatment with self-expandable braided stents (LEO and LVIS) required further investigation. PURPOSE: Our aim was to analyze the outcomes after treatment with braided stents. DATA SOURCES: A systematic search of 3 databases was performed for studies published from 2006 to 2017. STUDY SELECTION: According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we included studies reporting patients treated with LEO or LVIS stents. DATA ANALYSIS: Random-effects meta-analysis was used to pool the following: aneurysm occlusion rate, complications, and neurologic outcomes. DATA SYNTHESIS: Thirty-five studies evaluating 1426 patients treated with braided stents were included in this meta-analysis. Successful stent delivery and complete aneurysm occlusion were 97% (1041/1095; 95% CI, 95%-98%) (I2=44%) and 88.3% (1097/1256; 95% CI, 85%-91%) (I2= 72%), respectively. Overall, treatment-related complications were 7.4% (107/1317; 95% CI, 5%-9%) (I2= 44%). Ischemic/thromboembolic events (48/1324=2.4%; 95% CI, 1.5%-3.4%) (I2=27%) and in-stent thrombosis (35/1324=1.5%; 95% CI, 0.6%-1.7%) (I2=0%) were the most common complications. Treatment-related morbidity was 1.5% (30/1324; 95% CI, 0.9%-2%) and was comparable between the LEO and LVIS groups. Complication rates between the anterior (29/322 = 8.8%; 95% CI, 3.4%-12%) (I2= 41%) versus posterior circulation (10/84 = 10.5%; 95% CI, 4%-16%) (I2= 0%) and distal (30/303 = 8%; 95% CI, 4.5%-12%) (I2= 48%) versus proximal aneurysms (14/153 = 9%; 95% CI, 3%-13%) (I2= 46%) were comparable (P > .05). LIMITATIONS: Limitations were selection and publication biases. CONCLUSIONS: In this analysis, treatment with the LEO and LVIS stents was relatively safe and effective. The most common complications were periprocedural thromboembolisms and in-stent thrombosis. The rate of complications was comparable among anterior and posterior circulation aneurysms, as well as for proximal and distally located lesions.
UR - http://www.scopus.com/inward/record.url?scp=85056645598&partnerID=8YFLogxK
U2 - 10.3174/ajnr.A5804
DO - 10.3174/ajnr.A5804
M3 - Articulo en revista no especializada
C2 - 30262643
AN - SCOPUS:85056645598
SN - 0195-6108
VL - 39
SP - 2064
EP - 2069
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
IS - 11
ER -