TY - JOUR
T1 - The revised Trypanosoma cruzi subspecific nomenclature
T2 - Rationale, epidemiological relevance and research applications
AU - Zingales, Bianca
AU - Miles, Michael A.
AU - Campbell, David A.
AU - Tibayrenc, Michel
AU - Macedo, Andrea M.
AU - Teixeira, Marta M.G.
AU - Schijman, Alejandro G.
AU - Llewellyn, Martin S.
AU - Lages-Silva, Eliane
AU - Machado, Carlos R.
AU - Andrade, Sonia G.
AU - Sturm, Nancy R.
N1 - Funding Information:
BZ thanks the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Ministério de Ciência e Tecnologia/Conselho Nacional de Desenvolvimento Científico e Tecnológico/Ministério da Saúde (MCT/CNPq/MS-SCTIE-DECIT-Edital de Doenças Negligenciadas) for financial support. MAM and MSL thank the Wellcome Trust (UK) and European Union Seventh Program Grant 223034 (ChagasEpiNet) for financial support. DAC and NRS are supported by NIH award AI056034. We thank Michael Lewis and Matthew Yeo for comments on the manuscript.
PY - 2012/3
Y1 - 2012/3
N2 - The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and the understanding of the population structure of this parasite is critical because of the links to transmission cycles and disease. At present, T. cruzi is partitioned into six discrete typing units (DTUs), TcI-TcVI. Here we focus on the current status of taxonomy-related areas such as population structure, phylogeographical and eco-epidemiological features, and the correlation of DTU with natural and experimental infection. We also summarize methods for DTU genotyping, available for widespread use in endemic areas. For the immediate future multilocus sequence typing is likely to be the gold standard for population studies. We conclude that greater advances in our knowledge on pathogenic and epidemiological features of these parasites are expected in the coming decade through the comparative analysis of the genomes from isolates of various DTUs.
AB - The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and the understanding of the population structure of this parasite is critical because of the links to transmission cycles and disease. At present, T. cruzi is partitioned into six discrete typing units (DTUs), TcI-TcVI. Here we focus on the current status of taxonomy-related areas such as population structure, phylogeographical and eco-epidemiological features, and the correlation of DTU with natural and experimental infection. We also summarize methods for DTU genotyping, available for widespread use in endemic areas. For the immediate future multilocus sequence typing is likely to be the gold standard for population studies. We conclude that greater advances in our knowledge on pathogenic and epidemiological features of these parasites are expected in the coming decade through the comparative analysis of the genomes from isolates of various DTUs.
KW - Discrete typing unit
KW - Genotyping
KW - Hybridization
KW - Pathology
KW - Phylogeography
KW - Trypanosoma cruzi strains
UR - https://www.scopus.com/pages/publications/84857655347
U2 - 10.1016/j.meegid.2011.12.009
DO - 10.1016/j.meegid.2011.12.009
M3 - Articulo en revista no especializada
C2 - 22226704
AN - SCOPUS:84857655347
SN - 1567-1348
VL - 12
SP - 240
EP - 253
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
IS - 2
ER -
