Tendencia del PSA en pacientes con carcinoma de próstata metastásico manejados con orquiectomía vs. bloqueo hormonal con análogos de la hormona liberadora de gonadotrofinas

Nicolás Fernández, Nicolas Villareal, Rodolfo Varela

Producción científica: Artículos / NotasArtículo Científicorevisión exhaustiva

Resumen

Introduction: Current standard treatment for metastatic prostate carcinoma is hormone therapy.The two most commonly used treatments are orchiectomy and gonadotropin releasing hormone (GnRH) analogues, both being equivalent. There is no data regarding the PSA trends in our population. This is the first study that analyzes these issues, and will serve for future studies. Methods: A retrospective cohort study was performed on patients with metastatic prostate cancer (CaPM) who underwent orchiectomy or started treatment with GnRH analogues and were followed over time in order to evaluate the trends of PSA and other associated variables such as, patient age, initial PSA, Gleason score. and TNM. Results: A total of 124 patients were included in the study and divided into two groups; the Orchiectomy (OQ) and the GnRH analogues (BA) group. Monthly PSA records were analyzed and there were no differences in PSA levels over time in these two groups. Progression occurred earlier in the OQ group at 27 months vs 32 months in the BA group. Conclusions: Both treatments are equivalent. Progression occurred earlier in the OQ group. Further studies are needed to measure the specific impact of administrative and insurance issues in the treatment of these patients.

Título traducido de la contribuciónPSA trends in patients with metastatic prostate cancer managed by orquiectomyvs hormone block by gonadotropin releasing hormone analogues
Idioma originalEspañol
Páginas (desde-hasta)183-187
Número de páginas5
PublicaciónUrologia Colombiana
Volumen23
N.º3
DOI
EstadoPublicada - 1 dic. 2014
Publicado de forma externa

Palabras clave

  • Orchiectomy
  • Prostate specific antigen
  • Prostatic neoplasms
  • Testicular hormones
  • Testosterone

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Profundice en los temas de investigación de 'Tendencia del PSA en pacientes con carcinoma de próstata metastásico manejados con orquiectomía vs. bloqueo hormonal con análogos de la hormona liberadora de gonadotrofinas'. En conjunto forman una huella única.

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