TY - JOUR
T1 - Reactivation of chagas disease after autologous hematopoietic stem cell transplantation
AU - Chalela, Claudia Marcela
AU - Peña, Angela Maria
AU - Roa, Angela Maria
AU - Reyes, David L.
AU - Rueda, Jennifer Paola
AU - Salazar, Luis Antonio
AU - Rosales, Manuel
AU - Gomez, Edgar David
AU - Bernal, Edgar Augusto
AU - Melo, Claudia Lucia Sossa
N1 - Publisher Copyright:
© 2021, Sociedade Brasileira de Medicina Tropical. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.
AB - Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.
KW - Chagas disease
KW - Stem cell transplantation
KW - Trypanosoma cruzi
UR - http://www.scopus.com/inward/record.url?scp=85098283415&partnerID=8YFLogxK
U2 - 10.1590/0037-8682-0143-2020
DO - 10.1590/0037-8682-0143-2020
M3 - Artículo Científico
C2 - 33338116
AN - SCOPUS:85098283415
SN - 0037-8682
VL - 54
SP - 1
EP - 4
JO - Revista da Sociedade Brasileira de Medicina Tropical
JF - Revista da Sociedade Brasileira de Medicina Tropical
M1 - e20200143
ER -
