Potential Role of Antioxidants as Adjunctive Therapy in Chagas Disease

Juana P. Sánchez-Villamil, Paula K. Bautista-Ninõ, Norma C. Serrano, Melvin Y. Rincon, Nisha J. Garg

Resultado de la investigación: Artículos / NotasArticulo en revista no especializadarevisión exhaustiva

13 Citas (Scopus)


Chagas disease (CD) is one of the most important neglected tropical diseases in the American continent. Host-derived nitroxidative stress in response to Trypanosoma cruzi infection can induce tissue damage contributing to the progression of Chagas disease. Antioxidant supplementation has been suggested as adjuvant therapy to current treatment. In this article, we synthesize and discuss the current evidence regarding the use of antioxidants as adjunctive compounds to fight harmful reactive oxygen species and lower the tissue oxidative damage during progression of chronic Chagas disease. Several antioxidants evaluated in recent studies have shown potential benefits for the control of oxidative stress in the host's tissues. Melatonin, resveratrol, the combination of Vitamin C/Vitamin E (vitC/vitE) or curcumin/benznidazole, and mitochondria-targeted antioxidants seem to be beneficial in reducing plasma and cardiac levels of lipid peroxidation products. Nevertheless, further research is needed to validate beneficial effects of antioxidant therapies in Chagas disease.

Idioma originalInglés
Número de artículo9081813
PublicaciónOxidative Medicine and Cellular Longevity
EstadoPublicada - 2020
Publicado de forma externa


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