Research Project done to find out about the existing connection between knowledge and attitude towards sexuality by using ICT strategies in adolescents from 14 to 16 years old attending two public high schools with the objective of increasing the possibilities of offering teenagers with better tools to prevent unintended pregnancy and therefore promote critical thinking in them. The method used was experimental quantitative research with testing, post-testing, and implementation of didactic ICT teaching strategies as well as traditional techniques such as the use of the 'Pedagogical Suitcase', a teaching project sponsored by the Colombian Department of Education to promote Sexual Health among citizens. The main results did not show significant differences between the experimental group and the traditional group when the workshops about Sexual Health were over. However, there are differences in favor of the use of ICT strategies. In the experimental group there was a greater decrease in the number of students with low knowledge ranging from 6.5% to 2.2% compared to what happened to the control group which decreased from 8.7% to 6.5%. Regarding dimensions of attitudes towards sexuality, there were changes favoring feelings, behaviors, and thoughts, as well as those presented in the experimental group. Finally, it was concluded that the implementation of didactic ICT strategies in the education of sexuality in adolescents, favors the increment in the level of knowledge and favorable attitudes towards sexuality.