TY - JOUR
T1 - Escherichia coli as a model system to study DNA repair genes of eukaryotic organisms
AU - Augusto-Pinto, Luiz
AU - Regis Da Silva, Carlos Gustavo
AU - De Oliveira Lopes, Débora
AU - Machado-Silva, Alice
AU - Machado, Carlos Renato
PY - 2003
Y1 - 2003
N2 - The bacteria Escherichia coli has been widely employed in studies of eukaryotic DNA repair genes. Several eukaryotic genes have been cloned by functional complementation of mutant lineages of E. coli. We examined the similarities and differences among bacterial and eukaryotic DNA repair systems. Based on these data, we examined tools used for gene cloning and functional studies of DNA repair in eukaryotes, using this bacterial system as a model.
AB - The bacteria Escherichia coli has been widely employed in studies of eukaryotic DNA repair genes. Several eukaryotic genes have been cloned by functional complementation of mutant lineages of E. coli. We examined the similarities and differences among bacterial and eukaryotic DNA repair systems. Based on these data, we examined tools used for gene cloning and functional studies of DNA repair in eukaryotes, using this bacterial system as a model.
KW - DNA repair
KW - Escherichia coli
KW - Functional complementation
UR - http://www.scopus.com/inward/record.url?scp=3042559580&partnerID=8YFLogxK
M3 - Artículo Científico
C2 - 12917804
AN - SCOPUS:3042559580
SN - 1676-5680
VL - 2
SP - 77
EP - 91
JO - Genetics and Molecular Research
JF - Genetics and Molecular Research
IS - 1
ER -