Effects of calcium and parathyroid hormone on prostacyclin synthesis by vascular tissue

P. Lopez-Jaramillo, F. Guarner, S. Moncada

Producción científica: Artículos / NotasArtículo Científicorevisión exhaustiva

7 Citas (Scopus)

Resumen

Prostacyclin generation by rat aortic rings was studied at different calcium concentrations. Extracellular calcium influenced prostacyclin synthesis, as reflected by the release of 6-keto-PGF into the medium, in a concentration-dependent fashion. Calcium levels beyond the physiological range (1.12-1.25 mM unbound calcium) markedly stimulated 6-keto-PGF production when compared with calcium-free solutions. On the other hand, addition of purified parathyroid hormone did not change 6-keto-PGF production at any calcium concentration tested. These data suggest that parathyroid hormone has no direct effect on prostacyclin synthesis by vascular tissue, although it might influence prostacyclin generation through changes in extracellular calcium levels.

Idioma originalInglés
Páginas (desde-hasta)997-1005
Número de páginas9
PublicaciónLife Sciences
Volumen40
N.º10
DOI
EstadoPublicada - 9 mar. 1987
Publicado de forma externa

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