TY - JOUR
T1 - A longitudinal study of free leptin index in pre-eclamptic pregnancies
AU - Garcés, María Fernanda
AU - Buell-Acosta, Julieth Daniela
AU - Rodríguez-Navarro, Haiver Antonio
AU - Páez-Leal, María Carolina
AU - Maldonado-Acosta, Luis Miguel
AU - Peralta-Franco, Jhon Jairo
AU - Burgos-Cardenas, Álvaro Javier
AU - Ángel-Müller, Edith
AU - Parada-Baños, Arturo José
AU - Parra-Pineda, Mario Orlando
AU - Eslava-Schmalbach, Javier
AU - Escobar-Sarmiento, Camilo Andrés
AU - Lacunza, Ezequiel
AU - Caminos-Cepeda, Sofia Alexandra
AU - Castaño, Justo P
AU - Nogueiras, Rubén
AU - Dieguez, Carlos
AU - Ruiz-Parra, Ariel Iván
AU - Caminos, Jorge Eduardo
N1 - © 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
Funding Information:
This study was supported by government grants to the Universidad Nacional de Colombia (DIEB) and School of Medicine (código Hermes: 41439) and Ministerio de Ciencia, Tecnología e Innovación (Minciencias) (CD: 202010012913‐2019‐INV‐Colciencias). Additionally, this work was supported by grants from FEDER/Ministerio de Ciencia, Innovación y Universidades‐Agencia Estatal de Investigación (CD: BFU2017‐87721; RN: RTI2018‐099413‐B‐I00); Xunta de Galicia (RN: 2021‐CP085 and 2020‐PG0157).
Publisher Copyright:
© 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
PY - 2023/3/23
Y1 - 2023/3/23
N2 - The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case–control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy.
AB - The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case–control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy.
KW - free leptin index
KW - pregnancy
KW - Pre-eclampsia
KW - free leptin index
KW - pregnancy and pre-eclampsia
UR - http://www.scopus.com/inward/record.url?scp=85150917107&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/94c3968e-821c-384f-8df4-f83833519c5a/
U2 - 10.1111/jcmm.17707
DO - 10.1111/jcmm.17707
M3 - Artículo Científico
C2 - 36950780
SN - 1582-1838
VL - 27
SP - 1083
EP - 1094
JO - Journal of cellular and molecular medicine
JF - Journal of cellular and molecular medicine
IS - 8
ER -
