Uric acid and risk of pre-eclampsia: results from a large case–control study and meta-analysis of prospective studies

Claudia C. Colmenares-Mejia, Doris C. Quintero-Lesmes, Paula K. Bautista-Niño, Elizabeth Guío, Maria C. Paez, Mónica Beltrán, David Williams, Kathryn J. Gray, Juan P. Casas, Norma C. Serrano

Research output: Articles / NotesScientific Articlepeer-review

4 Scopus citations


To quantify the association between maternal uric acid levels and pre-eclampsia risk in a large collection of primigravid women. A case–control study (1365 cases of pre-eclampsia and 1886 normotensive controls) was conducted. Pre-eclampsia was defined as blood pressure ≥ 140/90 mmHg and proteinuria ≥ 300 mg/24 h. Sub-outcome analysis included early, intermediate, and late pre-eclampsia. Multivariable analysis for pre-eclampsia and its sub-outcomes was conducted using binary and multinomial logistic regression, respectively. Additionally, a systematic review and meta-analysis of cohort studies measuring uric acid levels < 20 weeks of gestation was performed to rule out reverse causation. There was a positive linear association between increasing uric acid levels and presence of pre-eclampsia. Adjusted odds ratio of pre-eclampsia was 1.21 (95%CI 1.11–1.33) for every one standard deviation increase in uric acid levels. No differences in the magnitude of association were observed between early and late pre-eclampsia. Three studies with uric acid measured < 20 weeks’ gestation were identified, with a pooled OR for pre-eclampsia of 1.46 (95%CI 1.22–1.75) for a top vs. bottom quartile comparison. Maternal uric acid levels are associated with risk of pre-eclampsia. Mendelian randomisation studies would be helpful to further explore the causal role of uric acid in pre-eclampsia.

Original languageEnglish
Article number3018
Pages (from-to)1-10
Number of pages10
JournalScientific reports
Issue number1
StatePublished - Dec 2023


  • Pregnancy
  • Female
  • Humans
  • Pre-Eclampsia
  • Prospective Studies
  • Uric Acid
  • Case-Control Studies
  • Blood Pressure/physiology


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