Trypanosoma cruzi: Genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease

Andréa M. Macedo, Carlos R. Machado, Riva P. Oliveira, Sérgio D.J. Pena

Research output: Contribution to journalReview articlepeer-review

234 Scopus citations

Abstract

Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or, occasionally, overwhelming acute episodes. The factors influencing this clinical variability have not been elucidated, but it is likely that the genetic variability of both the host and the parasite are of importance. In this work we review the the genetic structure of T. cruzi populations and analyze the importance of genetic variation of the parasite in the pathogenesis of the disease under the light of the histotropic-clonal model.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalMemorias do Instituto Oswaldo Cruz
Volume99
Issue number1
DOIs
StatePublished - Feb 2004
Externally publishedYes

Keywords

  • Chagas disease
  • Genetic variability
  • Mismatch repair
  • Pathogenesis
  • Population structure
  • Trypanosoma cruzi

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