TY - JOUR
T1 - The hypotensive effect of calcium supplementation during normal pregnancy in andean women is not related to vascular production of prostacyclin by umbilical arteries
AU - Fèlix, C.
AU - Jacome, P.
AU - Lòpez, A.
AU - Moya, W.
AU - Narvàez, M.
AU - Lòpez-Jaramillo, P.
PY - 1991
Y1 - 1991
N2 - Calcium supplementation during pregnancy attenuates maternal blood pressure and reduces the risk of pregnancy hypertension in Andean women with low calcium intake. Calcium supplementation might result in an increase in the vascular production of prostacyclin, and this might be responsible for the hypotensive effect of calcium supplementation. We measured the release of prostacyclin from umbilical arteries in two groups of nulliparous women:- 14 supplemented with 2 g elemental calcium daily from 20 weeks pregnant to delivery, and 11 assigned to placebo starch tablets. The levels of 6-keto-prostaglandin F1α were similar in both groups. However, the calcium supplemented group had a mean blood pressure (106 ± 8/70 ± 8 mmHg; s.d.), lower (P<0.05) than the placebo group (112 ± 10/74 ± 6 mmHg). Although these data confirm that calcium supplementation attenuates maternal blood pressure in normal pregnancy in these women, the hypotensive effect is unlikely to be mediated by an increased vascular production of prostacyclin.
AB - Calcium supplementation during pregnancy attenuates maternal blood pressure and reduces the risk of pregnancy hypertension in Andean women with low calcium intake. Calcium supplementation might result in an increase in the vascular production of prostacyclin, and this might be responsible for the hypotensive effect of calcium supplementation. We measured the release of prostacyclin from umbilical arteries in two groups of nulliparous women:- 14 supplemented with 2 g elemental calcium daily from 20 weeks pregnant to delivery, and 11 assigned to placebo starch tablets. The levels of 6-keto-prostaglandin F1α were similar in both groups. However, the calcium supplemented group had a mean blood pressure (106 ± 8/70 ± 8 mmHg; s.d.), lower (P<0.05) than the placebo group (112 ± 10/74 ± 6 mmHg). Although these data confirm that calcium supplementation attenuates maternal blood pressure in normal pregnancy in these women, the hypotensive effect is unlikely to be mediated by an increased vascular production of prostacyclin.
UR - http://www.scopus.com/inward/record.url?scp=0025851695&partnerID=8YFLogxK
U2 - 10.3109/01443619109013523
DO - 10.3109/01443619109013523
M3 - Artículo Científico
AN - SCOPUS:0025851695
SN - 0144-3615
VL - 11
SP - 93
EP - 96
JO - Journal of Obstetrics and Gynaecology
JF - Journal of Obstetrics and Gynaecology
IS - 2
ER -