The effects of hypoestrogenism on the vaginal wall: Interference with the normal sexual response

Lucia Alves da Silva Lara, Bernardo Useche, Rui Alberto Ferriani, Rosana Maria Reis, Marcos Felipe Silva De Sá, Mauricio Mesquita Sabino De Freitas, Julio César Rosa E Silva, Ana Carolina Japur De Sá Rosa E Silva

Research output: Articles / NotesArticle in a non-specialized journalpeer-review

63 Scopus citations


Introduction. The sexual response depends on the adequate function of all systems related to the genital and extra-genital organs. Physiological conditions such as menopause can interfere with sexual expression because of central and peripheral changes. Genital effects of estrogen include vaginal trophism, lubrication, and local pleasure sensation in the sexual arousal phase. Hypoestrogenism causes changes in the four layers of the vaginal wall that may result in dyspareunia and a loss in the quality of the genital arousal response. Aim. The purpose of this review is to highlight the changes in the vaginal wall caused by hypoestrogenism, its possible relationship with dyspareunia, and its repercussions for genital arousal. Treatments for hypoestrogenism are also discussed. Methods. We evaluated the data available in PubMed (1982-2008) and surveyed the reference list for relevant studies. Two reviewers analyzed the data independently. A study was considered to be of high quality if it had all three of the following characteristics: (i) prospective design; (ii) valid data; and (iii) adequate sample size. Reviews and experimental animal studies were also considered. Main Outcome Measures. Normal genital morphology, hypoestrogenism and hormone replacement therapy were the focus of the studies reviewed in this paper. Results. Atrophy of the vaginal wall may be associated with dyspareunia and genital sexual arousal disorder, but psychological and sociocultural aspects must also be considered. Regardless, however, local estrogen therapy is useful in improving vaginal wall trophism and, thus, in improving the sexual response. Conclusions. There are many possible alterations in the structure of the vaginal wall that are related to estrogen deficiency that may require medical intervention beyond the usual strategies used to attain adequate sexual function. Physicians should attempt to treat these alterations, and more research is needed to elucidate the physiopathology of dyspareunia and genital sexual arousal physiology.

Original languageEnglish
Pages (from-to)30-39
Number of pages10
JournalJournal of Sexual Medicine
Issue number1
StatePublished - 2009
Externally publishedYes


  • Dyspareunia
  • Estrogen
  • Female Sexual Function
  • Menopause
  • Sexual Arousal
  • Vaginal Wall


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