Reactivation of chagas disease after autologous hematopoietic stem cell transplantation

Claudia Marcela Chalela, Angela Maria Peña, Angela Maria Roa, David L. Reyes, Jennifer Paola Rueda, Luis Antonio Salazar, Manuel Rosales, Edgar David Gomez, Edgar Augusto Bernal, Claudia Lucia Sossa Melo

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.

Original languageEnglish
Article numbere20200143
Pages (from-to)1-4
Number of pages4
JournalRevista da Sociedade Brasileira de Medicina Tropical
Volume54
DOIs
StatePublished - 2021

Keywords

  • Chagas disease
  • Stem cell transplantation
  • Trypanosoma cruzi

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