TY - JOUR
T1 - Prevalence of metabolic syndrome in scholars from Bucaramanga, Colombia
T2 - A population-based study
AU - Villa-Roel, Cristina
AU - Buitrago, Adriana
AU - Rodríguez, Diana C.
AU - Cano, Diana J.
AU - Martínez, María P.
AU - Camacho, Paul A.
AU - Ruiz, Álvaro J.
AU - Durán, Álvaro E.
N1 - Funding Information:
CVR was responsible for the study design, coordinated the study conduct and will be responsible for the analyses and manuscript production. AB, DCR and DJC coordinated the study personnel, the recruitment phase and were responsible for data management. MPM and PAC contributed to the study design and to the submission for funding. Finally, AJR and AED participated in the study design and supported the group in the submission for funding.
PY - 2009/4/21
Y1 - 2009/4/21
N2 - Background: Obesity and metabolic syndrome are strongly associated with type 2 diabetes mellitus and cardiovascular diseases, thus the increasing trend in their prevalence among children and adolescents from developing countries requires a further understanding of their epidemiology and determinants. Methods and design: A cross-sectional study was designed to determine the prevalence of metabolic syndrome among 6-10 year-old children from Bucaramanga, Colombia. A two-stage random-cluster (neighborhoods, houses) sampling process was performed based on local city maps and local statistics. The study involves a domiciliary survey; including a comprehensive socio-demographic, nutritional and physical activity characterization of the children that participated in the study, followed by a complete clinical examination; including blood pressure, anthropometry, lipid profile determination, fasting glucose and insulin levels. The prevalence of metabolic syndrome will be determined using definitions and specific percentile cut-off points for this population. Finally, the association between components of metabolic syndrome and higher degrees of insulin resistance will be analyzed through a multivariable logistic regression model. This study protocol was designed in compliance with the Helsinki declaration and approved by the local ethics board. Consent was obtained from the children and their parents/guardians. Discussion: A complete description of the environmental and non-environmental factors underlying the burden of metabolic syndrome in children from a developing country like Colombia will provide policy makers, health care providers and educators from similar settings with an opportunity to guide primary and secondary preventive initiatives at both individual and community levels. Moreover, this description may give an insight into the pathophysiological mechanisms mediating the development of cardio-metabolic diseases early in life.
AB - Background: Obesity and metabolic syndrome are strongly associated with type 2 diabetes mellitus and cardiovascular diseases, thus the increasing trend in their prevalence among children and adolescents from developing countries requires a further understanding of their epidemiology and determinants. Methods and design: A cross-sectional study was designed to determine the prevalence of metabolic syndrome among 6-10 year-old children from Bucaramanga, Colombia. A two-stage random-cluster (neighborhoods, houses) sampling process was performed based on local city maps and local statistics. The study involves a domiciliary survey; including a comprehensive socio-demographic, nutritional and physical activity characterization of the children that participated in the study, followed by a complete clinical examination; including blood pressure, anthropometry, lipid profile determination, fasting glucose and insulin levels. The prevalence of metabolic syndrome will be determined using definitions and specific percentile cut-off points for this population. Finally, the association between components of metabolic syndrome and higher degrees of insulin resistance will be analyzed through a multivariable logistic regression model. This study protocol was designed in compliance with the Helsinki declaration and approved by the local ethics board. Consent was obtained from the children and their parents/guardians. Discussion: A complete description of the environmental and non-environmental factors underlying the burden of metabolic syndrome in children from a developing country like Colombia will provide policy makers, health care providers and educators from similar settings with an opportunity to guide primary and secondary preventive initiatives at both individual and community levels. Moreover, this description may give an insight into the pathophysiological mechanisms mediating the development of cardio-metabolic diseases early in life.
UR - http://www.scopus.com/inward/record.url?scp=65549098178&partnerID=8YFLogxK
U2 - 10.1186/1471-2431-9-28
DO - 10.1186/1471-2431-9-28
M3 - Artículo Científico
C2 - 19383169
AN - SCOPUS:65549098178
SN - 1471-2431
VL - 9
JO - BMC Pediatrics
JF - BMC Pediatrics
IS - 1
M1 - 28
ER -