Preeclampsia y riesgo cardiovascular: Estudio de seguimiento en la población de GenPE en Colombia

Translated title of the contribution: Pre-eclampsia and cardiovascular risk: A follow-up study of the GenPE population in Colombia

Norma Cecilia Serrano-Díaz, María Carolina Páez-Leal, Mónica Andrea Beltrán-Avendaño, Claudia Carolina Colmenares-Mejía, Elizabeth Guio-Mahecha, Paula Bautista-Niño, Colaboradores

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2 Scopus citations

Abstract

Introduction: Females having a background of pre-eclampsia (PE) are at greater risk of developing cardiovascular disease. The GenPE study has captured pregnant females with and without PE in Colombia during the last 10 years, making it possible today to evaluate cardiovascular outcomes in this group. Objective: Determining the presence of cardiovascular disease in young females who were and were not exposed to preclampsia and who were recruited by the GenPE study carried out in Bucaramanga, Colombia. Materials and methods: This was a cohort study which included 106 primiparous patients aged less than 26 years old having no background of chronic disease taken from an original cohort of 666 patients (2005-2010). They were physically examined and venopuncture was made for glycemia, lipid profile, uric acid and apolypoprotein A-I and B. The presence of hypertension, obesity, type 2 diabetes mellitus and metabolic syndrome were evaluated. Differences were established by Wilcoxon or Chisquared tests (relative risk and 95% CI) between females who had been exposed to PE and those who had not been so and the change between entering the GenPE study and the first follow-up. Results: An association was found between exposure to PE and having higher diastolic pressure figures (p = 0.003) and hypercholesterolemia (p = 0.040). Sub-optimal HDL cholesterol and apo A-I levels were found in the whole population. No association with strong outcomes was found during the first follow-up, such as hypertension, obesity, type 2 diabetes mellitus or metabolic syndrome. Conclusion: Changes in peripheral arterial disease (PAD) and cardiovascular risk-associated biomarkers became evident in a sample of young colombian females who developed PE during the first followup within 2 years after delivery.

Translated title of the contributionPre-eclampsia and cardiovascular risk: A follow-up study of the GenPE population in Colombia
Original languageSpanish
Pages (from-to)241-251
Number of pages11
JournalRevista Colombiana de Obstetricia y Ginecologia
Volume63
Issue number3
DOIs
StatePublished - 2012

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