Polypill: an affordable strategy for cardiovascular disease prevention in low–medium-income countries

Patricio López-Jaramillo, Silvia González-Gómez, Diego Zarate-Bernal, Andrés Serrano, Leonor Atuesta, Christian Clausen, Claudia Castro-Valencia, Paul Camacho-Lopez, Johanna Otero

Research output: Articles / NotesArticle in a non-specialized journalpeer-review

11 Scopus citations


The simplification of fixed dose medications by using a single ‘polypill’ is an attractive strategy to improve adherence to medications which has shown benefit to cardiovascular risk factor control and cardiovascular disease prevention or delay in the progression of these diseases. We review the evidence obtained from a series of clinical trials demonstrating an improvement in adherence to the polypill compared to the use of each compound separately, and found similar or better control of the classical cardiovascular risk factors and a similar safety profile. These results suggest that the use of the polypill could have a beneficial impact in cardiovascular morbidity and mortality. Furthermore, the polypill has the potential to improve cost effectiveness and is simple to use. However, before recommending the implementation of the polypill in programs aimed at primary and secondary cardiovascular prevention, we are awaiting the results of several current clinical trials aimed at measuring the impact on the frequency of major cardiovascular outcomes, particularly in low–medium-income countries.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalTherapeutic Advances in Cardiovascular Disease
Issue number6
StatePublished - 1 Jun 2018
Externally publishedYes


  • cardiovascular disease
  • compliance
  • fixed dose combination therapy
  • hypertension
  • polycap
  • polypill


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