TY - JOUR
T1 - Penetration of topically administered prednisolone acetate into the human aqueous humor
AU - Leibowitz, Howard M.
AU - Berrospi, Amado R.
AU - Kupferman, Allan
AU - Restropo, Guillermo Velez
AU - Galvis, Virgilio
AU - Alvarez, Juan Arango
N1 - Funding Information:
From the Department of Ophthalmology and the Massachusetts Lions Eye Research Laboratory, Boston University School of Medicine, Boston, Massachusetts (Drs. Leibowitz, Berrospi, Kupferman, and Galvis); the Department of Ophthalmology, National University of Antioquia, Medellin, Colombia, South America (Dr. Velez Restropo); and the Eye Clinic of the Lions Club of Cartagena, Cartagena, Colombia, South America (Dr. Arango Alvarez). This study was supported by a grant from the Massachusetts Lions Eye Research Fund and by a grant from Research to Prevent Blindness, Inc.
PY - 1977/3
Y1 - 1977/3
N2 - A single standardized drop of 1.0% prednisolone acetate labeled with tritiated thymidine was administered topically to one eye of 58 patients shortly before elective cataract extraction. An aqueous humor sample was aspirated at varying intervals and its corticosteroid content was determined. Peak drug concentration in aqueous humor was 1.13 μg/ml, which occurred 30 to 45 minutes after instillation of the medication. Substantial quantities of corticosteroid were found in the aqueous humor five minutes after drug administration. The area under the drug concentration in aqueous humor-vs-time curve (a measure of the drug's bioavailability in aqueous humor) was 88 μg min/ ml, and its half-life in human aqueous humor was 28 minutes. None of these values were significantly different from the comparable values in rabbit eyes.
AB - A single standardized drop of 1.0% prednisolone acetate labeled with tritiated thymidine was administered topically to one eye of 58 patients shortly before elective cataract extraction. An aqueous humor sample was aspirated at varying intervals and its corticosteroid content was determined. Peak drug concentration in aqueous humor was 1.13 μg/ml, which occurred 30 to 45 minutes after instillation of the medication. Substantial quantities of corticosteroid were found in the aqueous humor five minutes after drug administration. The area under the drug concentration in aqueous humor-vs-time curve (a measure of the drug's bioavailability in aqueous humor) was 88 μg min/ ml, and its half-life in human aqueous humor was 28 minutes. None of these values were significantly different from the comparable values in rabbit eyes.
UR - http://www.scopus.com/inward/record.url?scp=0017325028&partnerID=8YFLogxK
U2 - 10.1016/0002-9394(77)90740-1
DO - 10.1016/0002-9394(77)90740-1
M3 - Artículo Científico
C2 - 848546
AN - SCOPUS:0017325028
SN - 0002-9394
VL - 83
SP - 402
EP - 406
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 3
ER -