Penetration of topically administered prednisolone acetate into the human aqueous humor

Howard M. Leibowitz, Amado R. Berrospi, Allan Kupferman, Guillermo Velez Restropo, Virgilio Galvis, Juan Arango Alvarez

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A single standardized drop of 1.0% prednisolone acetate labeled with tritiated thymidine was administered topically to one eye of 58 patients shortly before elective cataract extraction. An aqueous humor sample was aspirated at varying intervals and its corticosteroid content was determined. Peak drug concentration in aqueous humor was 1.13 μg/ml, which occurred 30 to 45 minutes after instillation of the medication. Substantial quantities of corticosteroid were found in the aqueous humor five minutes after drug administration. The area under the drug concentration in aqueous humor-vs-time curve (a measure of the drug's bioavailability in aqueous humor) was 88 μg min/ ml, and its half-life in human aqueous humor was 28 minutes. None of these values were significantly different from the comparable values in rabbit eyes.

Original languageEnglish
Pages (from-to)402-406
Number of pages5
JournalAmerican Journal of Ophthalmology
Volume83
Issue number3
DOIs
StatePublished - Mar 1977
Externally publishedYes

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