Overview of DNA repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major

Danielle Gomes Passos-Silva, Matheus Andrade Rajão, Pedro Henrique Nascimento De Aguiar, João Pedro Vieira-Da-Rocha, Carlos Renato Machado, Carolina Furtado

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

A wide variety of DNA lesions arise due to environmental agents, normal cellular metabolism, or intrinsic weaknesses in the chemical bonds of DNA. Diverse cellular mechanisms have evolved to maintain genome stability, including mechanisms to repair damaged DNA, to avoid the incorporation of modified nucleotides, and to tolerate lesions (translesion synthesis). Studies of the mechanisms related to DNA metabolism in trypanosomatids have been very limited. Together with recent experimental studies, the genome sequencing of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, has revealed interesting features of the DNA repair mechanism in these protozoan parasites, which will be reviewed here.

Original languageEnglish
Article number840768
JournalJournal of Nucleic Acids
Volume2010
DOIs
StatePublished - 2010
Externally publishedYes

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