TY - JOUR
T1 - Overview of DNA repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major
AU - Passos-Silva, Danielle Gomes
AU - Rajão, Matheus Andrade
AU - Nascimento De Aguiar, Pedro Henrique
AU - Vieira-Da-Rocha, João Pedro
AU - Machado, Carlos Renato
AU - Furtado, Carolina
PY - 2010
Y1 - 2010
N2 - A wide variety of DNA lesions arise due to environmental agents, normal cellular metabolism, or intrinsic weaknesses in the chemical bonds of DNA. Diverse cellular mechanisms have evolved to maintain genome stability, including mechanisms to repair damaged DNA, to avoid the incorporation of modified nucleotides, and to tolerate lesions (translesion synthesis). Studies of the mechanisms related to DNA metabolism in trypanosomatids have been very limited. Together with recent experimental studies, the genome sequencing of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, has revealed interesting features of the DNA repair mechanism in these protozoan parasites, which will be reviewed here.
AB - A wide variety of DNA lesions arise due to environmental agents, normal cellular metabolism, or intrinsic weaknesses in the chemical bonds of DNA. Diverse cellular mechanisms have evolved to maintain genome stability, including mechanisms to repair damaged DNA, to avoid the incorporation of modified nucleotides, and to tolerate lesions (translesion synthesis). Studies of the mechanisms related to DNA metabolism in trypanosomatids have been very limited. Together with recent experimental studies, the genome sequencing of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, has revealed interesting features of the DNA repair mechanism in these protozoan parasites, which will be reviewed here.
UR - http://www.scopus.com/inward/record.url?scp=84860294717&partnerID=8YFLogxK
U2 - 10.4061/2010/840768
DO - 10.4061/2010/840768
M3 - Articulo en revista no especializada
AN - SCOPUS:84860294717
SN - 2090-0201
VL - 2010
JO - Journal of Nucleic Acids
JF - Journal of Nucleic Acids
M1 - 840768
ER -