Optimizing microdialysis for deep brain stimulation

William Omar Contreras Lopez, Erich Talamoni Fonoff, Clement Hamani, Travis S. Tierney, Eduardo Alho, Maria Gabriela Dos Santos Ghilardi, Manoel Jacobsen Teixeira, Raquel Chacon Ruiz Martinez

Research output: Articles / NotesArticle in a non-specialized journalpeer-review

8 Scopus citations


Cerebral microdialysis is a chemical detection method capable of identifying and simultaneously sampling a wide range of substances in the micromilieu of the monitoring probe. The interstitial space of biological tissues and fluids is sampled through a thin fenestrated dialysis catheter inserted into the brain. The technique has been reported in patients with Parkinson's disease. However, the procedure is not widely used by neurosurgeons, possibly owing to unclear indications and poor effective benefits, mostly secondary to significant pitfalls. In spite of the feasibility of microdialysis in humans, many factors can affect the quality of the process. Possible pitfalls include improperly designed probe, probe insertion effects, ineffective perfusion rate, issues to optimize stabilization period, and insufficient volume sample. This article reviews those key technical features necessary for performing microdialysis in humans during deep brain stimulation for Parkinson's Disease.

Original languageEnglish
Pages (from-to)299-310
Number of pages12
JournalFrontiers in Bioscience - Elite
Issue number2
StatePublished - 1 Jan 2016
Externally publishedYes


  • Deep brain stimulation
  • Metabolism
  • Microdialysis
  • Neurotransmitter
  • Review


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