Optical coherence tomography imaging of the basal ganglia: Feasibility and brief review

W. O.Contreras Lopez, J. S. Ângelos, R. C.R. Martinez, C. K. Takimura, M. J. Teixeira, P. A. Lemos Neto, E. T. Fonoff

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Optical coherence tomography (OCT) is a promising medical imaging technique that uses light to capture real-time crosssectional images from biological tissues in micrometer resolution. Commercially available optical coherence tomography systems are employed in diverse applications, including art conservation and diagnostic medicine, notably in cardiology and ophthalmology. Application of this technology in the brain may enable distinction between white matter and gray matter, and obtainment of detailed images from within the encephalon. We present, herein, the in vivo implementation of OCT imaging in the rat brain striatum. For this, two male 60-day-old rats (Rattus norvegicus, Albinus variation, Wistar) were stereotactically implanted with guide cannulas into the striatum to guide a 2.7-French diameter high-definition OCT imaging catheter (Dragonflyt, St. Jude Medical, USA). Obtained images were compared with corresponding histologically stained sections to collect imaging samples. A brief analysis of OCT technology and its current applications is also reported, as well as intracerebral OCT feasibility on brain mapping during neurosurgical procedures.

Original languageEnglish
Pages (from-to)1156-1159
Number of pages4
JournalBrazilian Journal of Medical and Biological Research
Volume48
Issue number12
DOIs
StatePublished - Dec 2015
Externally publishedYes

Keywords

  • Basal ganglia
  • Brain imaging
  • Histology
  • Optical coherence tomography (OCT)
  • Rat brain
  • Thalamus

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