Monitoring the functionalization of single-walled carbon nanotubes with chitosan and folic acid by two-dimensional diffusion-ordered NMR spectroscopy

John J. Castillo, Mary H. Torres, Daniel R. Molina, Jaime Castillo-León, Winnie E. Svendsen, Patricia Escobar, Fernando Martínez O.

Research output: Articles / NotesScientific Articlepeer-review

19 Scopus citations

Abstract

A conjugate between single-walled carbon nanotubes, chitosan and folic acid has been prepared. It was characterized by diffusion ordered two-dimensional hydrogen-1 nuclear magnetic resonance and hydrogen-1 nuclear magnetic resonance spectroscopy which revealed the presence of a conjugate that was generated by the linkage between the carboxyl moiety of the folic acid and the amino group of the chitosan, which in turn was non-covalently bound to the single-walled carbon nanotubes. The obtained diffusion coefficient values demonstrated that free folic acid diffused more rapidly than the folic acid conjugated to single-walled carbon nanotubes-chitosan. The values of the proton signal of hydrogen-1 nuclear magnetic resonance spectroscopy and two-dimensional hydrogen-1 nuclear magnetic resonance spectroscopy further confirmed that the folic acid was conjugated to the chitosan, wrapping the single-walled carbon nanotubes.

Original languageEnglish
Pages (from-to)2691-2697
Number of pages7
JournalCarbon
Volume50
Issue number8
DOIs
StatePublished - Jul 2012
Externally publishedYes

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