TY - JOUR
T1 - Interstitial brachytherapy with iodine-125 seeds for low grade brain stem gliomas in adults
T2 - Diagnostic and therapeutic intervention in a one-step procedure
AU - Lopez, William Omar Contreras
AU - Trippel, Michael
AU - Doostkam, Soroush
AU - Reithmeier, Thomas
PY - 2013/8
Y1 - 2013/8
N2 - Purpose: To report on iodine-125 (I125) interstitial irradiation in the treatment of low grade brain stem gliomas in adults. Patients and methods: Ten patients with well-circumscribed lesions of the brainstem and histological confirmation of low grade glioma treated with stereotactically implanted I-125 seed in our department between 1995 and 2012 were retrospectively analyzed. Results: In 9 patients the lesion was treated with one I-125 seed and in one patient, 2 spatial separated lesions were implanted, therefore a total of 11 I-125 seeds were implanted. The mean volume of the 11 lesions was 2.76 ml (range: 0.5-7.2 ml), mean activity of the seeds was 6.23 mCi (range: 1.5-11.1 mCi), mean duration of irradiation was 28.5 days (range: 21-41 days) and mean effective dose rate was 9.16 cGy/h (range: 6.2-12 cGy/h). The 30 days perioperative morbidity and mortality rate was 0%. Median follow up was 72.5 month (range 5-168 months). Six of ten patients were free of progression until last follow up. Conclusion: In our experience at the University Clinic in Freiburg Germany, interstitial radiosurgery based on MRI is a safe and effective method to diagnose and treat low grade gliomas of the brain stem. Furthermore randomized studies are needed to confirm the therapeutic impact of this method in comparison to external beam radiation of brain stem gliomas.
AB - Purpose: To report on iodine-125 (I125) interstitial irradiation in the treatment of low grade brain stem gliomas in adults. Patients and methods: Ten patients with well-circumscribed lesions of the brainstem and histological confirmation of low grade glioma treated with stereotactically implanted I-125 seed in our department between 1995 and 2012 were retrospectively analyzed. Results: In 9 patients the lesion was treated with one I-125 seed and in one patient, 2 spatial separated lesions were implanted, therefore a total of 11 I-125 seeds were implanted. The mean volume of the 11 lesions was 2.76 ml (range: 0.5-7.2 ml), mean activity of the seeds was 6.23 mCi (range: 1.5-11.1 mCi), mean duration of irradiation was 28.5 days (range: 21-41 days) and mean effective dose rate was 9.16 cGy/h (range: 6.2-12 cGy/h). The 30 days perioperative morbidity and mortality rate was 0%. Median follow up was 72.5 month (range 5-168 months). Six of ten patients were free of progression until last follow up. Conclusion: In our experience at the University Clinic in Freiburg Germany, interstitial radiosurgery based on MRI is a safe and effective method to diagnose and treat low grade gliomas of the brain stem. Furthermore randomized studies are needed to confirm the therapeutic impact of this method in comparison to external beam radiation of brain stem gliomas.
KW - Interstitial brachytherapy
KW - Iodine-125 seeds
KW - Isodose distribution
KW - Low grade brainstem gliomas in adults
KW - Radioactive isotopes and radiation dose
KW - University Clinic Freiburg Germany
UR - http://www.scopus.com/inward/record.url?scp=84880332332&partnerID=8YFLogxK
U2 - 10.1016/j.clineuro.2013.01.012
DO - 10.1016/j.clineuro.2013.01.012
M3 - Artículo Científico
C2 - 23465328
AN - SCOPUS:84880332332
SN - 0303-8467
VL - 115
SP - 1451
EP - 1456
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
IS - 8
ER -