High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study

Peter A. Kavsak, Mike Walsh, Sadeesh Srinathan, Laurel Thorlacius, Giovanna Lurati Buse, Fernando Botto, Shirley Pettit, Matthew J. McQueen, Stephen A. Hill, Sabu Thomas, Marko Mrkobrada, Pablo Alonso-Coello, Otavio Berwanger, Bruce M. Biccard, George Cembrowski, Matthew T.V. Chan, Clara K. Chow, Angeles de Miguel, Mercedes Garcia, Michelle M. GrahamMichael J. Jacka, J. H. Kueh, Stephen C.H. Li, Lydia C.W. Lit, Cecília Martínez-Brú, Prebashini Naidoo, Peter Nagele, Rupert M. Pearse, Reitze N. Rodseth, Daniel I. Sessler, Alben Sigamani, Wojciech Szczeklik, Maria Tiboni, Juan Carlos Villar, C. Y. Wang, Denis Xavier, P. J. Devereaux

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Objectives: To determine the proportion of noncardiac surgery patients exceeding the published 99th percentile or change criteria with the high sensitivity Troponin T (hs-TnT) assay. Design and methods: We measured hs-TnT preoperatively and postoperatively on days 1, 2 and 3 in 325 adults. Results: Postoperatively 45% (95% CI: 39-50%) of patients had hs-TnT. ≥. 14 ng/L and 22% (95% CI:17-26%) had an elevation (≥. 14 ng/L) and change (>. 85%) in hs-TnT. Conclusion: Further research is needed to inform the optimal hs-TnT threshold and change in this setting.

Original languageEnglish
Pages (from-to)1021-1024
Number of pages4
JournalClinical Biochemistry
Volume44
Issue number12
DOIs
StatePublished - Aug 2011

Keywords

  • 99th percentile
  • Concentration change
  • High sensitivity troponin T
  • Noncardiac surgery
  • Reference interval

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