High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study

Peter A. Kavsak; Mike Walsh; Sadeesh Srinathan; Laurel Thorlacius; Giovanna Lurati Buse; Fernando Botto; Shirley Pettit; Matthew J. McQueen; Stephen A. Hill; Sabu Thomas; Marko Mrkobrada; Pablo Alonso-Coello; Otavio Berwanger; Bruce M. Biccard; George Cembrowski; Matthew T.V. Chan; Clara K. Chow; Angeles de Miguel; Mercedes Garcia; Michelle M. Graham; Michael J. Jacka; J. H. Kueh; Stephen C.H. Li; Lydia C.W. Lit; Cecília Martínez-Brú; Prebashini Naidoo; Peter Nagele; Rupert M. Pearse; Reitze N. Rodseth; Daniel I. Sessler; Alben Sigamani; Wojciech Szczeklik; Maria Tiboni; Juan Carlos Villar; C. Y. Wang; Denis Xavier; P. J. Devereaux

doi:10.1016/j.clinbiochem.2011.05.017

High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study

Peter A. Kavsak, Mike Walsh, Sadeesh Srinathan, Laurel Thorlacius, Giovanna Lurati Buse, Fernando Botto, Shirley Pettit, Matthew J. McQueen, Stephen A. Hill, Sabu Thomas, Marko Mrkobrada, Pablo Alonso-Coello, Otavio Berwanger, Bruce M. Biccard, George Cembrowski, Matthew T.V. Chan, Clara K. Chow, Angeles de Miguel, Mercedes Garcia, Michelle M. GrahamMichael J. Jacka, J. H. Kueh, Stephen C.H. Li, Lydia C.W. Lit, Cecília Martínez-Brú, Prebashini Naidoo, Peter Nagele, Rupert M. Pearse, Reitze N. Rodseth, Daniel I. Sessler, Alben Sigamani, Wojciech Szczeklik, Maria Tiboni, Juan Carlos Villar, C. Y. Wang, Denis Xavier, P. J. Devereaux

Research output: Articles / Notes › Scientific Article › peer-review

79 Scopus citations

Abstract

Objectives: To determine the proportion of noncardiac surgery patients exceeding the published 99th percentile or change criteria with the high sensitivity Troponin T (hs-TnT) assay. Design and methods: We measured hs-TnT preoperatively and postoperatively on days 1, 2 and 3 in 325 adults. Results: Postoperatively 45% (95% CI: 39-50%) of patients had hs-TnT. ≥. 14 ng/L and 22% (95% CI:17-26%) had an elevation (≥. 14 ng/L) and change (>. 85%) in hs-TnT. Conclusion: Further research is needed to inform the optimal hs-TnT threshold and change in this setting.

Original language	English
Pages (from-to)	1021-1024
Number of pages	4
Journal	Clinical Biochemistry
Volume	44
Issue number	12
DOIs	https://doi.org/10.1016/j.clinbiochem.2011.05.017
State	Published - Aug 2011

Keywords

99th percentile
Concentration change
High sensitivity troponin T
Noncardiac surgery
Reference interval

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10.1016/j.clinbiochem.2011.05.017

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Kavsak, P. A., Walsh, M., Srinathan, S., Thorlacius, L., Buse, G. L., Botto, F., Pettit, S., McQueen, M. J., Hill, S. A., Thomas, S., Mrkobrada, M., Alonso-Coello, P., Berwanger, O., Biccard, B. M., Cembrowski, G., Chan, M. T. V., Chow, C. K., de Miguel, A., Garcia, M., ... Devereaux, P. J. (2011). High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study. Clinical Biochemistry, 44(12), 1021-1024. https://doi.org/10.1016/j.clinbiochem.2011.05.017

@article{fecf7586f5324bda88b82992a387c1fb,

title = "High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study",

abstract = "Objectives: To determine the proportion of noncardiac surgery patients exceeding the published 99th percentile or change criteria with the high sensitivity Troponin T (hs-TnT) assay. Design and methods: We measured hs-TnT preoperatively and postoperatively on days 1, 2 and 3 in 325 adults. Results: Postoperatively 45% (95% CI: 39-50%) of patients had hs-TnT. ≥. 14 ng/L and 22% (95% CI:17-26%) had an elevation (≥. 14 ng/L) and change (>. 85%) in hs-TnT. Conclusion: Further research is needed to inform the optimal hs-TnT threshold and change in this setting.",

keywords = "99th percentile, Concentration change, High sensitivity troponin T, Noncardiac surgery, Reference interval",

author = "Kavsak, {Peter A.} and Mike Walsh and Sadeesh Srinathan and Laurel Thorlacius and Buse, {Giovanna Lurati} and Fernando Botto and Shirley Pettit and McQueen, {Matthew J.} and Hill, {Stephen A.} and Sabu Thomas and Marko Mrkobrada and Pablo Alonso-Coello and Otavio Berwanger and Biccard, {Bruce M.} and George Cembrowski and Chan, {Matthew T.V.} and Chow, {Clara K.} and {de Miguel}, Angeles and Mercedes Garcia and Graham, {Michelle M.} and Jacka, {Michael J.} and Kueh, {J. H.} and Li, {Stephen C.H.} and Lit, {Lydia C.W.} and Cec{\'i}lia Mart{\'i}nez-Br{\'u} and Prebashini Naidoo and Peter Nagele and Pearse, {Rupert M.} and Rodseth, {Reitze N.} and Sessler, {Daniel I.} and Alben Sigamani and Wojciech Szczeklik and Maria Tiboni and Villar, {Juan Carlos} and Wang, {C. Y.} and Denis Xavier and Devereaux, {P. J.}",

note = "Funding Information: Funding and support for this study was obtained via grants from the CANadian Network and Centre for Trials Internationally (CANNeCTIN) , Canadian Institutes of Health Research , the Heart and Stroke Foundation of Ontario , Diagnostic Services of Manitoba , and Roche Diagnostics",

year = "2011",

month = aug,

doi = "10.1016/j.clinbiochem.2011.05.017",

language = "Ingl{\'e}s",

volume = "44",

pages = "1021--1024",

journal = "Clinical Biochemistry",

issn = "0009-9120",

publisher = "Elsevier Inc.",

number = "12",

}

Kavsak, PA, Walsh, M, Srinathan, S, Thorlacius, L, Buse, GL, Botto, F, Pettit, S, McQueen, MJ, Hill, SA, Thomas, S, Mrkobrada, M, Alonso-Coello, P, Berwanger, O, Biccard, BM, Cembrowski, G, Chan, MTV, Chow, CK, de Miguel, A, Garcia, M, Graham, MM, Jacka, MJ, Kueh, JH, Li, SCH, Lit, LCW, Martínez-Brú, C, Naidoo, P, Nagele, P, Pearse, RM, Rodseth, RN, Sessler, DI, Sigamani, A, Szczeklik, W, Tiboni, M, Villar, JC, Wang, CY, Xavier, D & Devereaux, PJ 2011, 'High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study', Clinical Biochemistry, vol. 44, no. 12, pp. 1021-1024. https://doi.org/10.1016/j.clinbiochem.2011.05.017

TY - JOUR

T1 - High sensitivity troponin T concentrations in patients undergoing noncardiac surgery

T2 - A prospective cohort study

AU - Kavsak, Peter A.

AU - Walsh, Mike

AU - Srinathan, Sadeesh

AU - Thorlacius, Laurel

AU - Buse, Giovanna Lurati

AU - Botto, Fernando

AU - Pettit, Shirley

AU - McQueen, Matthew J.

AU - Hill, Stephen A.

AU - Thomas, Sabu

AU - Mrkobrada, Marko

AU - Alonso-Coello, Pablo

AU - Berwanger, Otavio

AU - Biccard, Bruce M.

AU - Cembrowski, George

AU - Chan, Matthew T.V.

AU - Chow, Clara K.

AU - de Miguel, Angeles

AU - Garcia, Mercedes

AU - Graham, Michelle M.

AU - Jacka, Michael J.

AU - Kueh, J. H.

AU - Li, Stephen C.H.

AU - Lit, Lydia C.W.

AU - Martínez-Brú, Cecília

AU - Naidoo, Prebashini

AU - Nagele, Peter

AU - Pearse, Rupert M.

AU - Rodseth, Reitze N.

AU - Sessler, Daniel I.

AU - Sigamani, Alben

AU - Szczeklik, Wojciech

AU - Tiboni, Maria

AU - Villar, Juan Carlos

AU - Wang, C. Y.

AU - Xavier, Denis

AU - Devereaux, P. J.

N1 - Funding Information: Funding and support for this study was obtained via grants from the CANadian Network and Centre for Trials Internationally (CANNeCTIN) , Canadian Institutes of Health Research , the Heart and Stroke Foundation of Ontario , Diagnostic Services of Manitoba , and Roche Diagnostics

PY - 2011/8

Y1 - 2011/8

N2 - Objectives: To determine the proportion of noncardiac surgery patients exceeding the published 99th percentile or change criteria with the high sensitivity Troponin T (hs-TnT) assay. Design and methods: We measured hs-TnT preoperatively and postoperatively on days 1, 2 and 3 in 325 adults. Results: Postoperatively 45% (95% CI: 39-50%) of patients had hs-TnT. ≥. 14 ng/L and 22% (95% CI:17-26%) had an elevation (≥. 14 ng/L) and change (>. 85%) in hs-TnT. Conclusion: Further research is needed to inform the optimal hs-TnT threshold and change in this setting.

AB - Objectives: To determine the proportion of noncardiac surgery patients exceeding the published 99th percentile or change criteria with the high sensitivity Troponin T (hs-TnT) assay. Design and methods: We measured hs-TnT preoperatively and postoperatively on days 1, 2 and 3 in 325 adults. Results: Postoperatively 45% (95% CI: 39-50%) of patients had hs-TnT. ≥. 14 ng/L and 22% (95% CI:17-26%) had an elevation (≥. 14 ng/L) and change (>. 85%) in hs-TnT. Conclusion: Further research is needed to inform the optimal hs-TnT threshold and change in this setting.

KW - 99th percentile

KW - Concentration change

KW - High sensitivity troponin T

KW - Noncardiac surgery

KW - Reference interval

UR - http://www.scopus.com/inward/record.url?scp=79960313886&partnerID=8YFLogxK

U2 - 10.1016/j.clinbiochem.2011.05.017

DO - 10.1016/j.clinbiochem.2011.05.017

M3 - Artículo Científico

C2 - 21640092

AN - SCOPUS:79960313886

SN - 0009-9120

VL - 44

SP - 1021

EP - 1024

JO - Clinical Biochemistry

JF - Clinical Biochemistry

IS - 12

ER -

High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: A prospective cohort study

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Keywords

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