Abstract
Introduction: Handgrip strength (HGS) is a measure of skeletal muscle function. There is a correlation between the progression of heart failure (HF) and handgrip reduction.
Objective: to stablish the association between HGS, mortality and hospitalization rates at 18 months follow up in patients with HF.
Methods: a prospective, cohort study, was performed in HF patients belonging to the 2015 FORCE study. They were followed up for 18 months to determine the rate of hospitalization and death in relation to their basal HGS, NYHA functional class and ejection fraction.
Results: 95 out of 120 patients enrolled in the 2015 FORCE study were included. Seventeen patients had died, finding a mortality rate of 17.8%. The remaining 78 patients were followed up for 18 months. The frequency of hospitalization was 78%. In the bivariate analysis higher mortality risk was found in patients with low HGS, RR 2.9 IC 95% (1.11-7.59). This behavior was also observed in patients with NYHA functional class III and IV, in whom, lower HGS was associated with higher risk of mortality, RR 2.42 IC 95% (1.07-5.45).
In the multivariate model a significant association was found between the global functional class and mortality, with HR 2.63 IC 95% (1.4–4.94), being more significant in men. Regarding hospitalization, the mean HGS was lower in hospitalized women vs those who did not present the outcome (18 kg/f vs 22 kg/f p0.0261).
Conclusions: HGS in patients with HF has a significant correlation with NYHA functional class, mortality and hospitalization rates. Its measurement could be a useful tool to increase the detection of patients with advanced HF.
Objective: to stablish the association between HGS, mortality and hospitalization rates at 18 months follow up in patients with HF.
Methods: a prospective, cohort study, was performed in HF patients belonging to the 2015 FORCE study. They were followed up for 18 months to determine the rate of hospitalization and death in relation to their basal HGS, NYHA functional class and ejection fraction.
Results: 95 out of 120 patients enrolled in the 2015 FORCE study were included. Seventeen patients had died, finding a mortality rate of 17.8%. The remaining 78 patients were followed up for 18 months. The frequency of hospitalization was 78%. In the bivariate analysis higher mortality risk was found in patients with low HGS, RR 2.9 IC 95% (1.11-7.59). This behavior was also observed in patients with NYHA functional class III and IV, in whom, lower HGS was associated with higher risk of mortality, RR 2.42 IC 95% (1.07-5.45).
In the multivariate model a significant association was found between the global functional class and mortality, with HR 2.63 IC 95% (1.4–4.94), being more significant in men. Regarding hospitalization, the mean HGS was lower in hospitalized women vs those who did not present the outcome (18 kg/f vs 22 kg/f p0.0261).
Conclusions: HGS in patients with HF has a significant correlation with NYHA functional class, mortality and hospitalization rates. Its measurement could be a useful tool to increase the detection of patients with advanced HF.
| Original language | Undefined/Unknown |
|---|---|
| Journal | Trends in Medicine |
| DOIs | |
| State | Published - 1 Jan 2018 |
Enfoques Temáticos Institucionales
- Salud y bienestar
Research Areas UNAB
- Especialidades Quirúrgicas
