Expression pattern of protease activated receptors in lymphoid cells

Mercedes L. López, Natalia Soriano-Sarabia, Gustavo Bruges, María Elena Marquez, Klaus T. Preissner, M. Lienhard Schmitz, Holger Hackstein

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Protease-activated receptors (PARs) are a subfamily of four G-protein-coupled receptors mediating multiple functions. PARs expression was studied in subpopulations of human lymphocytes. Our results indicate that natural killer cells expressed mRNA for PAR1, PAR2 and PAR3, CD4+ T cells expressed PAR1 and PAR2, while γδ and CD8+ T cells only expressed PAR1. PAR4 was absent at mRNA level and B cells did not express any PAR. Analyses of the cell surface PARs expression by flow cytometry were consistent with the mRNA data and also between different donors. PAR1 is the most abundant member of the PAR family present in lymphocytes.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalCellular Immunology
Volume288
Issue number1-2
DOIs
StatePublished - Mar 2014
Externally publishedYes

Keywords

  • B cells
  • FACS
  • Lymphocytes
  • Protease-activated receptors

Fingerprint

Dive into the research topics of 'Expression pattern of protease activated receptors in lymphoid cells'. Together they form a unique fingerprint.

Cite this