Endothelial NO synthase genotype and risk of preeclampsia: A multicenter case-control study

Norma C. Serrano; Juan P. Casas; Luis A. Díaz; Carolina Páez; Clara M. Mesa; Rodrigo Cifuentes; Alvaro Monterrosa; Alejandro Bautista; Emma Hawe; Aroon D. Hingorani; Patrick Vallance; Patricio López-Jaramillo

doi:10.1161/01.HYP.0000143483.66701.ec

Endothelial NO synthase genotype and risk of preeclampsia: A multicenter case-control study

Norma C. Serrano, Juan P. Casas, Luis A. Díaz, Carolina Páez, Clara M. Mesa, Rodrigo Cifuentes, Alvaro Monterrosa, Alejandro Bautista, Emma Hawe, Aroon D. Hingorani, Patrick Vallance, Patricio López-Jaramillo

Medicina

Research output: Articles / Notes › Scientific Article › peer-review

125 Scopus citations

Abstract

Polymorphisms in the endothelial NO synthase (eNOS) gene have been evaluated as risk factors for preeclampsia. However, data from small studies are conflicting. We assessed whether eNOS genotypes alter the risk of preeclampsia in a population in which the incidence of this disorder is high. A total of 844 young pregnant women (322 preeclamptic and 522 controls) were recruited from 5 cities. Genotyping for the Glu298Asp, intron-4 and -786T→C polymorphisms in the eNOS gene was conducted. Multivariate odds ratios (ORs) were obtained to estimate the association of individual polymorphisms and haplotypes with preeclampsia risk. No increase in the risk of preeclampsia for the intron-4 or -786T→C polymorphisms was observed under any model of inheritance. In contrast, in women homozygous for the Asp298 allele, the adjusted OR for preeclampsia was 4.60 (95% confidence interval [CI], 1.73 to 12.22) compared with carriers of the Glu298 allele. After a multivariate analysis, carriage of the "Asp298-786C-4b" haplotype was also associated with increased risk of preeclampsia (OR, 2.11 [95% CI, 1.33 to 3.34]) compared with carriers of the "Glu298-786T-4b" haplotype. The eNOS Glu298Asp polymorphism and the Asp298-786C-4b haplotype are risk factors for preeclampsia.

Original language	English
Pages (from-to)	702-707
Number of pages	6
Journal	Hypertension
Volume	44
Issue number	5
DOIs	https://doi.org/10.1161/01.HYP.0000143483.66701.ec
State	Published - Nov 2004

Keywords

Case-control studies
Haplotypes
Nitric oxide synthase
Polymorphism
Preeclampsia

Access to Document

10.1161/01.HYP.0000143483.66701.ec

Cite this

@article{d387d429a7ca40fd91c280575f0820b0,

title = "Endothelial NO synthase genotype and risk of preeclampsia: A multicenter case-control study",

abstract = "Polymorphisms in the endothelial NO synthase (eNOS) gene have been evaluated as risk factors for preeclampsia. However, data from small studies are conflicting. We assessed whether eNOS genotypes alter the risk of preeclampsia in a population in which the incidence of this disorder is high. A total of 844 young pregnant women (322 preeclamptic and 522 controls) were recruited from 5 cities. Genotyping for the Glu298Asp, intron-4 and -786T→C polymorphisms in the eNOS gene was conducted. Multivariate odds ratios (ORs) were obtained to estimate the association of individual polymorphisms and haplotypes with preeclampsia risk. No increase in the risk of preeclampsia for the intron-4 or -786T→C polymorphisms was observed under any model of inheritance. In contrast, in women homozygous for the Asp298 allele, the adjusted OR for preeclampsia was 4.60 (95% confidence interval [CI], 1.73 to 12.22) compared with carriers of the Glu298 allele. After a multivariate analysis, carriage of the {"}Asp298-786C-4b{"} haplotype was also associated with increased risk of preeclampsia (OR, 2.11 [95% CI, 1.33 to 3.34]) compared with carriers of the {"}Glu298-786T-4b{"} haplotype. The eNOS Glu298Asp polymorphism and the Asp298-786C-4b haplotype are risk factors for preeclampsia.",

keywords = "Case-control studies, Haplotypes, Nitric oxide synthase, Polymorphism, Preeclampsia",

author = "Serrano, {Norma C.} and Casas, {Juan P.} and D{\'i}az, {Luis A.} and Carolina P{\'a}ez and Mesa, {Clara M.} and Rodrigo Cifuentes and Alvaro Monterrosa and Alejandro Bautista and Emma Hawe and Hingorani, {Aroon D.} and Patrick Vallance and Patricio L{\'o}pez-Jaramillo",

year = "2004",

month = nov,

doi = "10.1161/01.HYP.0000143483.66701.ec",

language = "Ingl{\'e}s",

volume = "44",

pages = "702--707",

journal = "Hypertension",

issn = "0194-911X",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

TY - JOUR

T1 - Endothelial NO synthase genotype and risk of preeclampsia

T2 - A multicenter case-control study

AU - Serrano, Norma C.

AU - Casas, Juan P.

AU - Díaz, Luis A.

AU - Páez, Carolina

AU - Mesa, Clara M.

AU - Cifuentes, Rodrigo

AU - Monterrosa, Alvaro

AU - Bautista, Alejandro

AU - Hawe, Emma

AU - Hingorani, Aroon D.

AU - Vallance, Patrick

AU - López-Jaramillo, Patricio

PY - 2004/11

Y1 - 2004/11

N2 - Polymorphisms in the endothelial NO synthase (eNOS) gene have been evaluated as risk factors for preeclampsia. However, data from small studies are conflicting. We assessed whether eNOS genotypes alter the risk of preeclampsia in a population in which the incidence of this disorder is high. A total of 844 young pregnant women (322 preeclamptic and 522 controls) were recruited from 5 cities. Genotyping for the Glu298Asp, intron-4 and -786T→C polymorphisms in the eNOS gene was conducted. Multivariate odds ratios (ORs) were obtained to estimate the association of individual polymorphisms and haplotypes with preeclampsia risk. No increase in the risk of preeclampsia for the intron-4 or -786T→C polymorphisms was observed under any model of inheritance. In contrast, in women homozygous for the Asp298 allele, the adjusted OR for preeclampsia was 4.60 (95% confidence interval [CI], 1.73 to 12.22) compared with carriers of the Glu298 allele. After a multivariate analysis, carriage of the "Asp298-786C-4b" haplotype was also associated with increased risk of preeclampsia (OR, 2.11 [95% CI, 1.33 to 3.34]) compared with carriers of the "Glu298-786T-4b" haplotype. The eNOS Glu298Asp polymorphism and the Asp298-786C-4b haplotype are risk factors for preeclampsia.

AB - Polymorphisms in the endothelial NO synthase (eNOS) gene have been evaluated as risk factors for preeclampsia. However, data from small studies are conflicting. We assessed whether eNOS genotypes alter the risk of preeclampsia in a population in which the incidence of this disorder is high. A total of 844 young pregnant women (322 preeclamptic and 522 controls) were recruited from 5 cities. Genotyping for the Glu298Asp, intron-4 and -786T→C polymorphisms in the eNOS gene was conducted. Multivariate odds ratios (ORs) were obtained to estimate the association of individual polymorphisms and haplotypes with preeclampsia risk. No increase in the risk of preeclampsia for the intron-4 or -786T→C polymorphisms was observed under any model of inheritance. In contrast, in women homozygous for the Asp298 allele, the adjusted OR for preeclampsia was 4.60 (95% confidence interval [CI], 1.73 to 12.22) compared with carriers of the Glu298 allele. After a multivariate analysis, carriage of the "Asp298-786C-4b" haplotype was also associated with increased risk of preeclampsia (OR, 2.11 [95% CI, 1.33 to 3.34]) compared with carriers of the "Glu298-786T-4b" haplotype. The eNOS Glu298Asp polymorphism and the Asp298-786C-4b haplotype are risk factors for preeclampsia.

KW - Case-control studies

KW - Haplotypes

KW - Nitric oxide synthase

KW - Polymorphism

KW - Preeclampsia

UR - http://www.scopus.com/inward/record.url?scp=7244236383&partnerID=8YFLogxK

U2 - 10.1161/01.HYP.0000143483.66701.ec

DO - 10.1161/01.HYP.0000143483.66701.ec

M3 - Artículo Científico

C2 - 15364897

AN - SCOPUS:7244236383

SN - 0194-911X

VL - 44

SP - 702

EP - 707

JO - Hypertension

JF - Hypertension

IS - 5

ER -

Endothelial NO synthase genotype and risk of preeclampsia: A multicenter case-control study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this