TY - JOUR
T1 - Effects of pregnancy-induced hypertension on the essential fatty acid statuses of Ecuadorian and Dutch women
AU - Otto, Suzie J.
AU - Van Houwelingen, Adriana C.
AU - López-Jaramillo, Patricio
AU - Hornstra, Gerard
PY - 1999
Y1 - 1999
N2 - OBJECTIVE: Among white Dutch women pregnancy-induced hypertension was shown to be associated with elevated levels of the long-chain polyenes of 18:2n-6 and 18:3n-3 in combination with reduced levels of those parent essential fatty acids. This observation suggested an enhanced desaturation and elongation of the parent fatty acids. This study was performed to investigate whether this phenomenon also occurs under completely different nutritional and geographic conditions. STUDY DESIGN: Plasma fatty acids of primiparous Mestizo Ecuadorian women with uncomplicated pregnancies and with pregnancy-induced hypertension were assessed at delivery and compared with similar data from white Dutch women. Neonatal values, as determined in umbilical plasma and umbilical vessel walls, were also compared. RESULTS: In contrast to the pattern seen among white mothers, pregnancy-induced hypertension did not increase the long-chain polyene status of Mestizo mothers. Despite the absence of this compensatory mechanism, long-chain polyene status was not compromised in Mestizo neonates born after pregnancy- induced hypertension. CONCLUSION: Additional mechanisms may be active in maintaining the long-chain polyene status of neonates born after pregnancy- induced hypertension.
AB - OBJECTIVE: Among white Dutch women pregnancy-induced hypertension was shown to be associated with elevated levels of the long-chain polyenes of 18:2n-6 and 18:3n-3 in combination with reduced levels of those parent essential fatty acids. This observation suggested an enhanced desaturation and elongation of the parent fatty acids. This study was performed to investigate whether this phenomenon also occurs under completely different nutritional and geographic conditions. STUDY DESIGN: Plasma fatty acids of primiparous Mestizo Ecuadorian women with uncomplicated pregnancies and with pregnancy-induced hypertension were assessed at delivery and compared with similar data from white Dutch women. Neonatal values, as determined in umbilical plasma and umbilical vessel walls, were also compared. RESULTS: In contrast to the pattern seen among white mothers, pregnancy-induced hypertension did not increase the long-chain polyene status of Mestizo mothers. Despite the absence of this compensatory mechanism, long-chain polyene status was not compromised in Mestizo neonates born after pregnancy- induced hypertension. CONCLUSION: Additional mechanisms may be active in maintaining the long-chain polyene status of neonates born after pregnancy- induced hypertension.
KW - Desaturation
KW - Elongation
KW - Essential fatty acids
KW - Long-chain polyenes
KW - Pregnancy-induced hypertension
UR - http://www.scopus.com/inward/record.url?scp=0033042395&partnerID=8YFLogxK
U2 - 10.1016/S0002-9378(99)70614-9
DO - 10.1016/S0002-9378(99)70614-9
M3 - Artículo Científico
C2 - 10329875
AN - SCOPUS:0033042395
SN - 0002-9378
VL - 180
SP - 1185
EP - 1190
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 5
ER -