Effects of calcium and parathyroid hormone on prostacyclin synthesis by vascular tissue

P. Lopez-Jaramillo; F. Guarner; S. Moncada

doi:10.1016/0024-3205(87)90320-1

Effects of calcium and parathyroid hormone on prostacyclin synthesis by vascular tissue

P. Lopez-Jaramillo, F. Guarner, S. Moncada

Research output: Articles / Notes › Scientific Article › peer-review

7 Scopus citations

Abstract

Prostacyclin generation by rat aortic rings was studied at different calcium concentrations. Extracellular calcium influenced prostacyclin synthesis, as reflected by the release of 6-keto-PGF_1α into the medium, in a concentration-dependent fashion. Calcium levels beyond the physiological range (1.12-1.25 mM unbound calcium) markedly stimulated 6-keto-PGF_1α production when compared with calcium-free solutions. On the other hand, addition of purified parathyroid hormone did not change 6-keto-PGF_1α production at any calcium concentration tested. These data suggest that parathyroid hormone has no direct effect on prostacyclin synthesis by vascular tissue, although it might influence prostacyclin generation through changes in extracellular calcium levels.

Original language	English
Pages (from-to)	997-1005
Number of pages	9
Journal	Life Sciences
Volume	40
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(87)90320-1
State	Published - 9 Mar 1987
Externally published	Yes

Access to Document

10.1016/0024-3205(87)90320-1

Cite this

@article{2a7edb26f5644416ad64c1ec37acdeb0,

title = "Effects of calcium and parathyroid hormone on prostacyclin synthesis by vascular tissue",

abstract = "Prostacyclin generation by rat aortic rings was studied at different calcium concentrations. Extracellular calcium influenced prostacyclin synthesis, as reflected by the release of 6-keto-PGF1α into the medium, in a concentration-dependent fashion. Calcium levels beyond the physiological range (1.12-1.25 mM unbound calcium) markedly stimulated 6-keto-PGF1α production when compared with calcium-free solutions. On the other hand, addition of purified parathyroid hormone did not change 6-keto-PGF1α production at any calcium concentration tested. These data suggest that parathyroid hormone has no direct effect on prostacyclin synthesis by vascular tissue, although it might influence prostacyclin generation through changes in extracellular calcium levels.",

author = "P. Lopez-Jaramillo and F. Guarner and S. Moncada",

year = "1987",

month = mar,

day = "9",

doi = "10.1016/0024-3205(87)90320-1",

language = "Ingl{\'e}s",

volume = "40",

pages = "997--1005",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "10",

}

TY - JOUR

T1 - Effects of calcium and parathyroid hormone on prostacyclin synthesis by vascular tissue

AU - Lopez-Jaramillo, P.

AU - Guarner, F.

AU - Moncada, S.

PY - 1987/3/9

Y1 - 1987/3/9

N2 - Prostacyclin generation by rat aortic rings was studied at different calcium concentrations. Extracellular calcium influenced prostacyclin synthesis, as reflected by the release of 6-keto-PGF1α into the medium, in a concentration-dependent fashion. Calcium levels beyond the physiological range (1.12-1.25 mM unbound calcium) markedly stimulated 6-keto-PGF1α production when compared with calcium-free solutions. On the other hand, addition of purified parathyroid hormone did not change 6-keto-PGF1α production at any calcium concentration tested. These data suggest that parathyroid hormone has no direct effect on prostacyclin synthesis by vascular tissue, although it might influence prostacyclin generation through changes in extracellular calcium levels.

AB - Prostacyclin generation by rat aortic rings was studied at different calcium concentrations. Extracellular calcium influenced prostacyclin synthesis, as reflected by the release of 6-keto-PGF1α into the medium, in a concentration-dependent fashion. Calcium levels beyond the physiological range (1.12-1.25 mM unbound calcium) markedly stimulated 6-keto-PGF1α production when compared with calcium-free solutions. On the other hand, addition of purified parathyroid hormone did not change 6-keto-PGF1α production at any calcium concentration tested. These data suggest that parathyroid hormone has no direct effect on prostacyclin synthesis by vascular tissue, although it might influence prostacyclin generation through changes in extracellular calcium levels.

UR - http://www.scopus.com/inward/record.url?scp=45949128168&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(87)90320-1

DO - 10.1016/0024-3205(87)90320-1

M3 - Artículo Científico

AN - SCOPUS:45949128168

SN - 0024-3205

VL - 40

SP - 997

EP - 1005

JO - Life Sciences

JF - Life Sciences

IS - 10

ER -

Effects of calcium and parathyroid hormone on prostacyclin synthesis by vascular tissue

Abstract

Access to Document

Other files and links

Fingerprint

Cite this