Abstract
Prostacyclin generation by rat aortic rings was studied at different calcium concentrations. Extracellular calcium influenced prostacyclin synthesis, as reflected by the release of 6-keto-PGF(1α) into the medium, in a concentration-dependent fashion. Calcium levels beyond the physiological range (1.12-1.25 mM unbound calcium) markedly stimulated 6-keto-PGF(1α) production when compared with calcium-free solutions. On the other hand, addition of purified parathyroid hormone did not change 6-keto-PGF(1α) production at any calcium concentration tested. These data suggest that parathyroid hormone has no direct effect on prostacyclin synthesis by vascular tissue, although it might influence prostacyclin generation through changes in extracellular calcium levels.
| Original language | English |
|---|---|
| Pages (from-to) | 983-986 |
| Number of pages | 4 |
| Journal | Life Sciences |
| Volume | 40 |
| Issue number | 10 |
| DOIs | |
| State | Published - 1987 |
| Externally published | Yes |