Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction

C. HERNÁNDEZ‐CASSIS; C. CURE‐CURE; P. LÓPEZ‐JARAMILLO

doi:10.1111/j.1365-2362.1995.tb01729.x

Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction

C. HERNÁNDEZ‐CASSIS
, C. CURE‐CURE
, P. LÓPEZ‐JARAMILLO

Research output: Articles / Notes › Scientific Article › peer-review

9 Scopus citations

Abstract

Abstract. The effect of thyroid replacement therapy (TRT) was evaluated in 372 children with minimal thyroid dysfunction (MTD; augmented TSH response to TRH, deficient iodine consumption, goiter, short stature and retarded bone age), by comparison of pre‐with post‐observation height in periods of 6 months with and without TRT alternated. A significant (P <0.05) height recovery was observed when children received TRT; however, during the period without TRT they showed a negative height recovery. Additionally, we followed 51 children with MTD who were observed from Tanner I until final height. The group with L‐thyroxine (n= 43) during all follow‐up (97 months) showed an important recovery in height (SDS‐H = 1.67 ± 0.93 vs. 1.08 ± 0.74) which when compared with the untreated group (n= 8; 114 months; SDS‐H = ‐1.50 ± 0.83 vs. ‐1.93 ± 0.33) was significant (P < 0.001).

Original language	English
Pages (from-to)	454-456
Number of pages	3
Journal	European Journal of Clinical Investigation
Volume	25
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2362.1995.tb01729.x
State	Published - Jun 1995
Externally published	Yes

Keywords

Minimal thyroid dysfunction
stature
thyroid replacement therapy

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10.1111/j.1365-2362.1995.tb01729.x

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title = "Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction",

abstract = "Abstract. The effect of thyroid replacement therapy (TRT) was evaluated in 372 children with minimal thyroid dysfunction (MTD; augmented TSH response to TRH, deficient iodine consumption, goiter, short stature and retarded bone age), by comparison of pre‐with post‐observation height in periods of 6 months with and without TRT alternated. A significant (P <0.05) height recovery was observed when children received TRT; however, during the period without TRT they showed a negative height recovery. Additionally, we followed 51 children with MTD who were observed from Tanner I until final height. The group with L‐thyroxine (n= 43) during all follow‐up (97 months) showed an important recovery in height (SDS‐H = 1.67 ± 0.93 vs. 1.08 ± 0.74) which when compared with the untreated group (n= 8; 114 months; SDS‐H = ‐1.50 ± 0.83 vs. ‐1.93 ± 0.33) was significant (P < 0.001).",

keywords = "Minimal thyroid dysfunction, stature, thyroid replacement therapy",

author = "C. HERN{\'A}NDEZ‐CASSIS and C. CURE‐CURE and P. L{\'O}PEZ‐JARAMILLO",

year = "1995",

month = jun,

doi = "10.1111/j.1365-2362.1995.tb01729.x",

language = "Ingl{\'e}s",

volume = "25",

pages = "454--456",

journal = "European Journal of Clinical Investigation",

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TY - JOUR

T1 - Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction

AU - HERNÁNDEZ‐CASSIS, C.

AU - CURE‐CURE, C.

AU - LÓPEZ‐JARAMILLO, P.

PY - 1995/6

Y1 - 1995/6

N2 - Abstract. The effect of thyroid replacement therapy (TRT) was evaluated in 372 children with minimal thyroid dysfunction (MTD; augmented TSH response to TRH, deficient iodine consumption, goiter, short stature and retarded bone age), by comparison of pre‐with post‐observation height in periods of 6 months with and without TRT alternated. A significant (P <0.05) height recovery was observed when children received TRT; however, during the period without TRT they showed a negative height recovery. Additionally, we followed 51 children with MTD who were observed from Tanner I until final height. The group with L‐thyroxine (n= 43) during all follow‐up (97 months) showed an important recovery in height (SDS‐H = 1.67 ± 0.93 vs. 1.08 ± 0.74) which when compared with the untreated group (n= 8; 114 months; SDS‐H = ‐1.50 ± 0.83 vs. ‐1.93 ± 0.33) was significant (P < 0.001).

AB - Abstract. The effect of thyroid replacement therapy (TRT) was evaluated in 372 children with minimal thyroid dysfunction (MTD; augmented TSH response to TRH, deficient iodine consumption, goiter, short stature and retarded bone age), by comparison of pre‐with post‐observation height in periods of 6 months with and without TRT alternated. A significant (P <0.05) height recovery was observed when children received TRT; however, during the period without TRT they showed a negative height recovery. Additionally, we followed 51 children with MTD who were observed from Tanner I until final height. The group with L‐thyroxine (n= 43) during all follow‐up (97 months) showed an important recovery in height (SDS‐H = 1.67 ± 0.93 vs. 1.08 ± 0.74) which when compared with the untreated group (n= 8; 114 months; SDS‐H = ‐1.50 ± 0.83 vs. ‐1.93 ± 0.33) was significant (P < 0.001).

KW - Minimal thyroid dysfunction

KW - stature

KW - thyroid replacement therapy

UR - https://www.scopus.com/pages/publications/0029051604

U2 - 10.1111/j.1365-2362.1995.tb01729.x

DO - 10.1111/j.1365-2362.1995.tb01729.x

M3 - Artículo Científico

C2 - 7656926

AN - SCOPUS:0029051604

SN - 0014-2972

VL - 25

SP - 454

EP - 456

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

IS - 6

ER -

Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction

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Keywords

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