TY - JOUR
T1 - Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction
AU - HERNÁNDEZ‐CASSIS, C.
AU - CURE‐CURE, C.
AU - LÓPEZ‐JARAMILLO, P.
PY - 1995/6
Y1 - 1995/6
N2 - Abstract. The effect of thyroid replacement therapy (TRT) was evaluated in 372 children with minimal thyroid dysfunction (MTD; augmented TSH response to TRH, deficient iodine consumption, goiter, short stature and retarded bone age), by comparison of pre‐with post‐observation height in periods of 6 months with and without TRT alternated. A significant (P <0.05) height recovery was observed when children received TRT; however, during the period without TRT they showed a negative height recovery. Additionally, we followed 51 children with MTD who were observed from Tanner I until final height. The group with L‐thyroxine (n= 43) during all follow‐up (97 months) showed an important recovery in height (SDS‐H = 1.67 ± 0.93 vs. 1.08 ± 0.74) which when compared with the untreated group (n= 8; 114 months; SDS‐H = ‐1.50 ± 0.83 vs. ‐1.93 ± 0.33) was significant (P < 0.001).
AB - Abstract. The effect of thyroid replacement therapy (TRT) was evaluated in 372 children with minimal thyroid dysfunction (MTD; augmented TSH response to TRH, deficient iodine consumption, goiter, short stature and retarded bone age), by comparison of pre‐with post‐observation height in periods of 6 months with and without TRT alternated. A significant (P <0.05) height recovery was observed when children received TRT; however, during the period without TRT they showed a negative height recovery. Additionally, we followed 51 children with MTD who were observed from Tanner I until final height. The group with L‐thyroxine (n= 43) during all follow‐up (97 months) showed an important recovery in height (SDS‐H = 1.67 ± 0.93 vs. 1.08 ± 0.74) which when compared with the untreated group (n= 8; 114 months; SDS‐H = ‐1.50 ± 0.83 vs. ‐1.93 ± 0.33) was significant (P < 0.001).
KW - Minimal thyroid dysfunction
KW - stature
KW - thyroid replacement therapy
UR - http://www.scopus.com/inward/record.url?scp=0029051604&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2362.1995.tb01729.x
DO - 10.1111/j.1365-2362.1995.tb01729.x
M3 - Artículo Científico
C2 - 7656926
AN - SCOPUS:0029051604
SN - 0014-2972
VL - 25
SP - 454
EP - 456
JO - European Journal of Clinical Investigation
JF - European Journal of Clinical Investigation
IS - 6
ER -