Efecto del aceite esencial de Eucalyptus citriodora sobre el metabolismo energético mitocondrial

Luis Carlos Vesga; Yenny Bueno; Elena E. Stashenko; Stelia C. Mendez-Sanchez

doi:10.15446/rev.colomb.quim.v43n2.53118

Efecto del aceite esencial de Eucalyptus citriodora sobre el metabolismo energético mitocondrial

Translated title of the contribution: Essential oil Eucalyptus citriodora effect on mitochondrial energy metabolism

Luis Carlos Vesga, Yenny Bueno, Elena E. Stashenko, Stelia C. Mendez-Sanchez

Research output: Articles / Notes › Scientific Article › peer-review

1 Scopus citations

Abstract

In order to contribute to the knowledge of its activity at the cellular level, the mechanism of action of the essential oil of Eucalyptus citriodora (Fam. Myrtaceae) on mitochondrial bioenergetics, the rate of oxygen consumption of energized mitochondria (states was assessed 3 and 4), and respiratory control ratio (CCR) were evaluated. The activity of the respiratory chain complexes was analyzed using spectrophotometric techniques. The results indicate that the essential oil of E. citriodora increases the rate of oxygen consumption in states 3 and 4, reduces the CCR, uncouples oxidative phosphorylation, increases the activity of cytochrome c oxidase, and increases the ATPase activity in mitochondria intact at concentrations ≥ 10 mg/mL. These results suggest that the essential oil or its metabolites affect the normal operation of the electron transport in the respiratory chain and ATP synthesis.

Translated title of the contribution	Essential oil Eucalyptus citriodora effect on mitochondrial energy metabolism
Original language	Spanish
Pages (from-to)	10-17
Number of pages	8
Journal	Revista Colombiana de Quimica
Volume	43
Issue number	2
DOIs	https://doi.org/10.15446/rev.colomb.quim.v43n2.53118
State	Published - May 2014
Externally published	Yes

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title = "Efecto del aceite esencial de Eucalyptus citriodora sobre el metabolismo energ{\'e}tico mitocondrial",

abstract = "In order to contribute to the knowledge of its activity at the cellular level, the mechanism of action of the essential oil of Eucalyptus citriodora (Fam. Myrtaceae) on mitochondrial bioenergetics, the rate of oxygen consumption of energized mitochondria (states was assessed 3 and 4), and respiratory control ratio (CCR) were evaluated. The activity of the respiratory chain complexes was analyzed using spectrophotometric techniques. The results indicate that the essential oil of E. citriodora increases the rate of oxygen consumption in states 3 and 4, reduces the CCR, uncouples oxidative phosphorylation, increases the activity of cytochrome c oxidase, and increases the ATPase activity in mitochondria intact at concentrations ≥ 10 mg/mL. These results suggest that the essential oil or its metabolites affect the normal operation of the electron transport in the respiratory chain and ATP synthesis.",

keywords = "Cytochrome c oxidase, Eucalyptus, Mitochondria, Oxidative phosphorylation",

author = "Vesga, {Luis Carlos} and Yenny Bueno and Stashenko, {Elena E.} and Mendez-Sanchez, {Stelia C.}",

year = "2014",

month = may,

doi = "10.15446/rev.colomb.quim.v43n2.53118",

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T1 - Efecto del aceite esencial de Eucalyptus citriodora sobre el metabolismo energético mitocondrial

AU - Vesga, Luis Carlos

AU - Bueno, Yenny

AU - Stashenko, Elena E.

AU - Mendez-Sanchez, Stelia C.

PY - 2014/5

Y1 - 2014/5

N2 - In order to contribute to the knowledge of its activity at the cellular level, the mechanism of action of the essential oil of Eucalyptus citriodora (Fam. Myrtaceae) on mitochondrial bioenergetics, the rate of oxygen consumption of energized mitochondria (states was assessed 3 and 4), and respiratory control ratio (CCR) were evaluated. The activity of the respiratory chain complexes was analyzed using spectrophotometric techniques. The results indicate that the essential oil of E. citriodora increases the rate of oxygen consumption in states 3 and 4, reduces the CCR, uncouples oxidative phosphorylation, increases the activity of cytochrome c oxidase, and increases the ATPase activity in mitochondria intact at concentrations ≥ 10 mg/mL. These results suggest that the essential oil or its metabolites affect the normal operation of the electron transport in the respiratory chain and ATP synthesis.

AB - In order to contribute to the knowledge of its activity at the cellular level, the mechanism of action of the essential oil of Eucalyptus citriodora (Fam. Myrtaceae) on mitochondrial bioenergetics, the rate of oxygen consumption of energized mitochondria (states was assessed 3 and 4), and respiratory control ratio (CCR) were evaluated. The activity of the respiratory chain complexes was analyzed using spectrophotometric techniques. The results indicate that the essential oil of E. citriodora increases the rate of oxygen consumption in states 3 and 4, reduces the CCR, uncouples oxidative phosphorylation, increases the activity of cytochrome c oxidase, and increases the ATPase activity in mitochondria intact at concentrations ≥ 10 mg/mL. These results suggest that the essential oil or its metabolites affect the normal operation of the electron transport in the respiratory chain and ATP synthesis.

KW - Cytochrome c oxidase

KW - Eucalyptus

KW - Mitochondria

KW - Oxidative phosphorylation

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U2 - 10.15446/rev.colomb.quim.v43n2.53118

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SN - 0120-2804

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Efecto del aceite esencial de Eucalyptus citriodora sobre el metabolismo energético mitocondrial

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