TY - JOUR
T1 - Cymbopogon flexuosus (nees ex steud.) w. watson essential oil effect on mitochondrial bioenergetics
AU - Montagut, Diana Carolina
AU - Bueno, Yenny
AU - Vesga, Luis C.
AU - Stashenko, Elena E.
AU - Mendez-Sanchez, Stelia C.
N1 - Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Cymbopogon flexuosus is a medicinal plant with various biological activities. Although its essential oil (EO) is widely used, the effect of C. flexuosus EO on mitochondrial bioenergetics has not been completely elucidated. Here, we report the effect of C. flexuosus EO on electron transport through the mitochondrial respiratory chain using isolated mitochondria from liver rats. The EO decreases the oxygen consumption rate up to −20% at 10 ppm, and −17% at 25 ppm using glutamate and succinate, respectively. The C. flexuosus EO inhibits the NADH oxidase (34%), succinate oxidase (53%), succinate dehydrogenase (44%), and cytochrome c oxidase (69%) activities at 10 ppm, which indicates a robust inhibitory effect on the electron transport chain. Our results show the inhibitory effect of C. flexuosus EO on electron transport through complex II and IV and suggest that this EO could be used as a potential drug to treat mitochondrial diseases, including cancer.
AB - Cymbopogon flexuosus is a medicinal plant with various biological activities. Although its essential oil (EO) is widely used, the effect of C. flexuosus EO on mitochondrial bioenergetics has not been completely elucidated. Here, we report the effect of C. flexuosus EO on electron transport through the mitochondrial respiratory chain using isolated mitochondria from liver rats. The EO decreases the oxygen consumption rate up to −20% at 10 ppm, and −17% at 25 ppm using glutamate and succinate, respectively. The C. flexuosus EO inhibits the NADH oxidase (34%), succinate oxidase (53%), succinate dehydrogenase (44%), and cytochrome c oxidase (69%) activities at 10 ppm, which indicates a robust inhibitory effect on the electron transport chain. Our results show the inhibitory effect of C. flexuosus EO on electron transport through complex II and IV and suggest that this EO could be used as a potential drug to treat mitochondrial diseases, including cancer.
KW - Cymbopogon flexuosus
KW - electron transport inhibition
KW - mitochondria
UR - http://www.scopus.com/inward/record.url?scp=85126894977&partnerID=8YFLogxK
U2 - 10.1080/10412905.2022.2050315
DO - 10.1080/10412905.2022.2050315
M3 - Artículo Científico
AN - SCOPUS:85126894977
SN - 1041-2905
VL - 34
SP - 233
EP - 239
JO - Journal of Essential Oil Research
JF - Journal of Essential Oil Research
IS - 3
ER -
