Concordancia de dos pruebas serológicas para el diagnóstico de la enfermedad de Chagas

Translated title of the contribution: Concordance of two serological tests for the diagnosis of Chagas disease

Ana E. Farfán-García, Yeny Z. Castellanos-Domínguez, Katherine P. Luna-Marín, Víctor M. Angulo-Silva

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

OBJECTIVE: Establish the concordance between in-house ELISA and IIF for the diagnosis of infection with T. cruzi using blood eluates.

METHODOLOGY: A study of diagnostic technology evaluation and cross-sectional sample of 650 residents of an endemic area of Colombia was conducted. It was determined the Receiver Operating Characteristic curve (ROC) and IIF was used as a gold standard. It was established the cutoff for the ELISA and the correlation between readings.

RESULTS: The in-house ELISA it was an agreement of 0.99 (95 % CI: 0.989 to 0.992) between the two readings taken and the area for the ROC curve was 0.9795. The cutoff was set at 0.5 absorbance in the ELISA test. 16.6 % were positive by ELISA and 10.9 % by IIF.

CONCLUSIONS: The in-house ELISA showed good concordance compared to the IIF, so it is a good choice diagnostic for the population living in remote areas.

Translated title of the contributionConcordance of two serological tests for the diagnosis of Chagas disease
Original languageSpanish
Pages (from-to)208-219
Number of pages12
JournalRevista de Salud Publica
Volume15
Issue number2
StatePublished - 1 Mar 2013
Externally publishedYes

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