Clinical neurotransplantation protocol for Huntington's and Parkinson's disease

William Omar Contreras Lopez, Guido Nikkhah, Ulf D. Kahlert, Donata Maciaczyk, Tomasz Bogiel, Sven Moellers, Elisabeth Schültke, Máté Döbrössy, Jaroslaw Maciaczyk

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Purpose: The concept of transplantation of neuronal cells to treat Huntington's and Parkinson's diseases is based on the proven principle that dopaminergic and GABA-ergic progenitor neurons (from the human developing ventral mesencephalon and whole ganglionic eminence) can survive, differentiate and functionally integrate into an allogenic host brain. However, several donor and host-specific variables play a major role in the safety and outcome of this procedure. In this paper, we seek to summarize an updated neural transplantation protocol, based on our institutional experience and many years of collaboration with other neurotransplantation centers. Methods: We present a detailed clinical neurotransplantation protocol for Parkinson's (PD) and Huntington's (HD) diseases with special emphasis in understanding the anatomical relationships of the human fetal tissue that are relevant for selection of the desired cell populations. Results: Two detailed step-wise neurotransplantation protocols are presented, outlining strategies facilitating the avoidance of possible procedure-related complications. Conclusions: In this paper we delineated some crucial technical factors enabling the execution of a safe and effective neural transplantation. The protocols presented here might contribute to further development of the experimental clinical neurotransplantation towards a routine therapeutic procedure.

Original languageEnglish
Pages (from-to)579-595
Number of pages17
JournalRestorative Neurology and Neuroscience
Volume31
Issue number5
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • good clinical practice (GCP)
  • Human fetal neural precursor cells (hFNPCs)
  • Huntington's disease (HD)
  • neural stem cells (NSC)
  • neural transplantation
  • Parkinson's disease (PD)
  • substantia nigra (SN)
  • ventral mesencephalon (VM)
  • whole ganglionic eminence (WGE)

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