TY - JOUR
T1 - Childhood leukemia in small geographical areas and proximity to industrial sources of air pollutants in three colombian cities
AU - Rodriguez-Villamizar, Laura Andrea
AU - Moreno-Corzo, Feisar Enrique
AU - Valbuena-Garcia, Ana María
AU - Pérez, Claudia Janeth Uribe
AU - Bohórquez, Mary Ruth Brome
AU - García, Héctor Iván García
AU - Bravo, Luis Eduardo
AU - Martínez, Rafael Gustavo Ortiz
AU - Velásquez, Jürg Niederbacher
AU - Osornio-Vargas, Alvaro R.
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Acute leukemia is the most common childhood cancer and has been associated with exposure to environmental carcinogens. This study aimed to identify clusters of acute childhood leukemia (ACL) cases and analyze their relationship with proximity to industrial sources of air pollution in three capital cities in Colombia during 2000–2015. Incident ACL cases were obtained from the population cancer registries for the cities of Bucaramanga, Cali, and Medellín. The inventory of industrial sources of emissions to the air was obtained from the regional environmental authorities and industrial conglomerates were identified. The Kulldorf’s circular scan test was used to detect city clusters and to identify clusters around industrial conglomerates. Multivariable spatial modeling assessed the effect of distance and direction from the industrial conglomerates controlling for socioeconomic status. We identified industrials sectors within a buffer of 1 km around industrial conglomerates related to the ACL clusters. Incidence rates showed geographical heterogeneity with low spatial autocorrelation within cities. The spatio-temporal tests identified one cluster in each city. The industries located within 1 km around the ACL clusters identified in the three cities represent different sectors. Exposure to air pollution from industrial sources might be contributing to the incidence of ACL cases in urban settings in Colombia.
AB - Acute leukemia is the most common childhood cancer and has been associated with exposure to environmental carcinogens. This study aimed to identify clusters of acute childhood leukemia (ACL) cases and analyze their relationship with proximity to industrial sources of air pollution in three capital cities in Colombia during 2000–2015. Incident ACL cases were obtained from the population cancer registries for the cities of Bucaramanga, Cali, and Medellín. The inventory of industrial sources of emissions to the air was obtained from the regional environmental authorities and industrial conglomerates were identified. The Kulldorf’s circular scan test was used to detect city clusters and to identify clusters around industrial conglomerates. Multivariable spatial modeling assessed the effect of distance and direction from the industrial conglomerates controlling for socioeconomic status. We identified industrials sectors within a buffer of 1 km around industrial conglomerates related to the ACL clusters. Incidence rates showed geographical heterogeneity with low spatial autocorrelation within cities. The spatio-temporal tests identified one cluster in each city. The industries located within 1 km around the ACL clusters identified in the three cities represent different sectors. Exposure to air pollution from industrial sources might be contributing to the incidence of ACL cases in urban settings in Colombia.
KW - Air pollution
KW - Childhood
KW - Cluster analysis
KW - Colombia
KW - Industrial pollution
KW - Leukemia
UR - http://www.scopus.com/inward/record.url?scp=85095389346&partnerID=8YFLogxK
U2 - 10.3390/ijerph17217925
DO - 10.3390/ijerph17217925
M3 - Artículo Científico
C2 - 33137878
AN - SCOPUS:85095389346
SN - 1661-7827
VL - 17
SP - 1
EP - 17
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
IS - 21
M1 - 7925
ER -
