Calcium plus linoleic acid therapy for pregnancy-induced hypertension

J. A. Herrera, A. K.M. Shahabuddin, G. Ersheng, Yuan Wei, R. G. Garcia, P. López-Jaramillo

Research output: Articles / NotesScientific Articlepeer-review

37 Scopus citations

Abstract

Objective: To determine the effect of dietary supplementation of calcium plus conjugated linoleic acid (calcium-CLA) in reducing the incidence of vascular endothelial dysfunction in pregnant women at high risk of developing pregnancy-induced hypertension (PIH). Patients and methods: This randomized, double-blind, placebo-controlled trial conducted at 4 outpatient clinics in 2 developing countries recruited 48 healthy primigravidas younger than 19 years or older than 35 years who had a family history of pre-eclampsia and diastolic notch. Twenty-four participants received daily elemental calcium (600 mg) plus CLA (450 mg) and 24 received placebo from week 18 to 22 of pregnancy until delivery. Results: Calcium-CLA supplementation reduced significantly the incidence of PIH (2 cases [8%] in the study group vs. 10 cases [42%] in the placebo group; relative risk, 0.20; 95% confidence interval, 0.05-0.82; P = .01). Endothelial dysfunction was also significantly reduced after calcium-CLA supplementation (in 18 women [75%] vs. 4 women [17%]; P < .001), compared with the placebo group (in 15 [63%] vs. 9 women [38%]; P = .08). Conclusion: In pregnant women at high risk for PIH, calcium-CLA supplementation decreases the incidence of PIH and improves endothelial function.

Original languageEnglish
Pages (from-to)221-227
Number of pages7
JournalInternational Journal of Gynecology and Obstetrics
Volume91
Issue number3
DOIs
StatePublished - Dec 2005
Externally publishedYes

Keywords

  • Calcium
  • Conjugated linoleic acid
  • Pre-eclampsia
  • Pregnancy-induced hypertension
  • Prevention
  • Vascular endothelial function

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