C-reactive protein, interleukin-6 and pre-eclampsia: large-scale evidence from the GenPE case-control study

Norma C. Serrano, Elizabeth Guio, Silvia M. Becerra-Bayona, Doris C. Quintero-Lesmes, Paula K. Bautista-Niño, Claudia Colmenares-Mejía, María C. Páez, María L. Luna, Luis A. Díaz, Ricardo Ortiz, Mónica Beltrán, Álvaro Monterrosa, Yezid Miranda, Clara M. Mesa, Wilmar Saldarriaga, Juan P. Casas

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Multiple small studies have suggested that women with pre-eclampsia present elevated levels of C-reactive protein (CRP) and interleukin-6 (IL-6). However, little is known regarding the source of this CRP and IL-6 increase. Therefore, the aim of this study was to evaluate the relationship between CRP and IL-6 levels with pre-eclampsia considering different confounding factors. Using data from a large Colombian case-control study (3,590 cases of pre-eclampsia and 4,564 normotensive controls), CRP and IL-6 levels were measured in 914 cases and 1297 controls. The association between maternal serum levels of CRP and IL-6 with pre-eclampsia risk was evaluated using adjusted logistic regression models. Pre-eclampsia was defined as presence of blood pressure ≥140/90 mmHg and proteinuria ≥300mg/24 h (or ≥1 + dipstick). There was no evidence of association between high levels of CRP and IL-6 with pre-eclampsia after adjusting for the following factors: maternal and gestational age, ethnicity, place and year of recruitment, multiple-pregnancy, socio-economic position, smoking, and presence of infections during pregnancy. The adjusted OR for 1SD increase in log-CRP and log-IL-6 was 0.96 (95%CI 0.85, 1.08) and 1.09 (95%CI 0.97, 1.22), respectively. Although previous reports have suggested an association between high CRP and IL-6 levels with pre-eclampsia, sample size may lack the sufficient power to draw robust conclusions, and this association is likely to be explained by unaccounted biases. Our results, the largest case-control study reported up to date, demonstrate that there is not a causal association between elevated levels of CRP and IL-6 and the presence of pre-eclampsia.

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume80
Issue number5
DOIs
StatePublished - 1 Sep 2020

Keywords

  • C-reactive protein
  • Colombia
  • Pre-eclampsia
  • case-control studies
  • inflammation
  • interleukin-6

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