Beyond reproduction: Exploring the Non-Canonical roles of the Kisspeptin System in Diverse Biological Systems: Exploring the Non-Canonical roles of the Kisspeptin System in Diverse Biological Systems

Deisy Yurley Rodríguez Sarmiento

doi:10.21931/RB/2023.08.03.13

Beyond reproduction: Exploring the Non-Canonical roles of the Kisspeptin System in Diverse Biological Systems: Exploring the Non-Canonical roles of the Kisspeptin System in Diverse Biological Systems

Deisy Yurley Rodríguez Sarmiento

Research output: Articles / Notes › Scientific Article › peer-review

1 Scopus citations

Abstract

Los receptores acoplados a proteína G son proteínas de membrana integrales en los procesos de señalización celular. La activación de los receptores acoplados a la proteína G por agonistas específicos promueve la activación de diferentes proteínas G, activando diferentes vías de señalización intracelular, incluida la activación de la adenilato ciclasa y la liberación de calcio intracelular. Uno de los receptores acoplados a la proteína G estudiados es el receptor de kisspeptina, que regula la reproducción y la secreción de gonadotropinas. Sin embargo, estudios recientes han demostrado que la kisspeptina y su receptor tienen funciones no canónicas en la señalización celular y en varios sistemas biológicos. En la presente revisión presentaremos estas diferentes funciones que ejerce el sistema kisspeptina en diferentes sistemas biológicos, como el sistema nervioso central, el sistema cardiovascular y el sistema inmunológico, así como el papel de este sistema en patologías como la preeclampsia. , diabetes y cáncer. Comprender sus funciones no canónicas en la señalización celular puede tener implicaciones importantes en el desarrollo de nuevas terapias para diversas enfermedades.

Original language	English
Article number	13
Number of pages	6
Journal	Bionatura
Volume	8
Issue number	3
DOIs	https://doi.org/10.21931/RB/2023.08.03.13
State	Published - 2023

Keywords

Cancer
Diabetes Mellitus
G-protein coupled receptor
Kisspeptin-1 Receptor
Kisspeptins
Preeclampsia
Signal Transduction

Research Areas UNAB

Nuevos medicamentos y tecnologías en salud

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21931/RB/2023.08.03.13

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title = "Beyond reproduction: Exploring the Non-Canonical roles of the Kisspeptin System in Diverse Biological Systems: Exploring the Non-Canonical roles of the Kisspeptin System in Diverse Biological Systems",

abstract = "G protein-coupled receptors are integral membrane proteins that are involved in cell signaling process-es. Activation of G protein-coupled receptors by specific agonists, promote the activation of different G-proteins which in turn activate different intracellular signaling pathways, including adenylate cyclase activation and intracellular calcium release. One of the G protein-coupled receptors studied is the kisspeptin receptor, which is involved in the regulation of reproduction and gonadotropin secre-tion. However, recent studies have shown that kisspeptin and its receptor have non-canonical roles in cell signaling and several biological systems. In the present review, we will present these different functions exerted by the kisspeptin system in different biological systems such as the central nervous system, the cardiovascular system, and the immune system, as well as the role of this system in pa-thologies such as preeclampsia, diabetes, and cancer. Understanding their non-canonical roles in cell signaling may have important implications in the development of new therapies for various diseases.",

keywords = "Cancer, Diabetes Mellitus, G-protein coupled receptor, Kisspeptin-1 Receptor, Kisspeptins, Preeclampsia, Signal Transduction, Kisspeptin-1 Receptor, Kisspeptins, GPCR, Cancer, Signal Transduction",

author = "{Rodr{\'i}guez Sarmiento}, {Deisy Yurley}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2023",

doi = "10.21931/RB/2023.08.03.13",

language = "Ingl{\'e}s",

volume = "8",

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AU - Rodríguez Sarmiento, Deisy Yurley

PY - 2023

Y1 - 2023

N2 - G protein-coupled receptors are integral membrane proteins that are involved in cell signaling process-es. Activation of G protein-coupled receptors by specific agonists, promote the activation of different G-proteins which in turn activate different intracellular signaling pathways, including adenylate cyclase activation and intracellular calcium release. One of the G protein-coupled receptors studied is the kisspeptin receptor, which is involved in the regulation of reproduction and gonadotropin secre-tion. However, recent studies have shown that kisspeptin and its receptor have non-canonical roles in cell signaling and several biological systems. In the present review, we will present these different functions exerted by the kisspeptin system in different biological systems such as the central nervous system, the cardiovascular system, and the immune system, as well as the role of this system in pa-thologies such as preeclampsia, diabetes, and cancer. Understanding their non-canonical roles in cell signaling may have important implications in the development of new therapies for various diseases.

AB - G protein-coupled receptors are integral membrane proteins that are involved in cell signaling process-es. Activation of G protein-coupled receptors by specific agonists, promote the activation of different G-proteins which in turn activate different intracellular signaling pathways, including adenylate cyclase activation and intracellular calcium release. One of the G protein-coupled receptors studied is the kisspeptin receptor, which is involved in the regulation of reproduction and gonadotropin secre-tion. However, recent studies have shown that kisspeptin and its receptor have non-canonical roles in cell signaling and several biological systems. In the present review, we will present these different functions exerted by the kisspeptin system in different biological systems such as the central nervous system, the cardiovascular system, and the immune system, as well as the role of this system in pa-thologies such as preeclampsia, diabetes, and cancer. Understanding their non-canonical roles in cell signaling may have important implications in the development of new therapies for various diseases.

KW - Cancer

KW - Diabetes Mellitus

KW - G-protein coupled receptor

KW - Kisspeptin-1 Receptor

KW - Kisspeptins

KW - Preeclampsia

KW - Signal Transduction

KW - Kisspeptin-1 Receptor

KW - Kisspeptins

KW - GPCR

KW - Cancer

KW - Signal Transduction

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DO - 10.21931/RB/2023.08.03.13

M3 - Artículo Científico

AN - SCOPUS:85171855165

SN - 1390-9347

VL - 8

JO - Bionatura

JF - Bionatura

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ER -

Beyond reproduction: Exploring the Non-Canonical roles of the Kisspeptin System in Diverse Biological Systems: Exploring the Non-Canonical roles of the Kisspeptin System in Diverse Biological Systems

Abstract

Keywords

Research Areas UNAB

UN SDGs

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