B-cell lymphocytosis in relatives of Colombian patients with chronic B-cell lymphoproliferative disorders

Mike Celis, Yohanna Navarro, Norma Serrano, Daniel Martínez, Wendy Nieto

Research output: Articles / NotesScientific Articlepeer-review

1 Scopus citations

Abstract

Introduction. Monoclonal B-cell lymphocytosis generally precedes chronic lymphocytic leukemia, affecting about 12% of the healthy adult population. This frequency increases in relatives of patients with chronic B-cell lymphoproliferative disorders. Objective. To determine the frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic B-cell lymphoproliferative disorders, their immunophenotypic/cytogenetic characteristics, a possible relationship with infectious agents, and short-term follow-up in the Colombian population. Materials and methods. Fifty healthy adults with a family history of chronic B-cell lymphoproliferative disorders were studied using multiparametric flow cytometry, cytogenetic/serological testing, lifestyle survey, and 2-year follow-up. Results. The frequency of monoclonal B-cell lymphocytosis found was 8%, with a predominance of female gender and advanced age, increasing to 12.5% for individuals with a family history of chronic lymphocytic leukemia. Three out of four individuals presented chronic lymphocytic leukemia-type immunophenotype, all with low counts. In turn, a significantly higher number of cells/μl is observed in these individuals in T lymphocyte subpopulations, together with a greater predisposition to the disease. The described clonal opulations increase over time in a non-significant manner. Conclusions. The frequency and behavior of monoclonal B-cell lymphocytosis in patients with family history of chronic B-cell lymphoproliferative disorders are like those found in related studies, which suggests that there is no involvement of more relevant genes that can trigger uncontrolled clonal proliferation, but that generates immunological deregulation that could justify a greater risk of serious infection in these individuals.

Translated title of the contributionLinfocitosis monoclonal de células B en familiars de pacientes colombianos con síndromes linfoproliferativos crónicos B
Original languageEnglish
Pages (from-to)66-78
Number of pages13
JournalBiomedica
Volume43
DOIs
StatePublished - 2023
Externally publishedYes

Keywords

  • citometría de flujo
  • estudios de seguimiento
  • flow cytometry
  • follow-up studies
  • leucemia linfocítica crónica de células b
  • leukemia, lymphocytic, chronic, b-cell
  • linfocitosis
  • linfoma no Hodgkin
  • Lymphocytosis
  • lymphoma
  • non-Hodgkin
  • pruebas serológicas
  • serologic tests

Fingerprint

Dive into the research topics of 'B-cell lymphocytosis in relatives of Colombian patients with chronic B-cell lymphoproliferative disorders'. Together they form a unique fingerprint.

Cite this