TY - JOUR
T1 - Association of ultra-processed food intake with risk of inflammatory bowel disease
T2 - Prospective cohort study
AU - Narula, Neeraj
AU - Wong, Emily C.L.
AU - Dehghan, Mahshid
AU - Mente, Andrew
AU - Rangarajan, Sumathy
AU - Lanas, Fernando
AU - Lopez-Jaramillo, Patricio
AU - Rohatgi, Priyanka
AU - Lakshmi, P. V.M.
AU - Varma, Ravi Prasad
AU - Orlandini, Andres
AU - Avezum, Alvaro
AU - Wielgosz, Andreas
AU - Poirier, Paul
AU - Almadi, Majid A.
AU - Altuntas, Yuksel
AU - Ng, Kien Keat
AU - Chifamba, Jephat
AU - Yeates, Karen
AU - Puoane, Thandi
AU - Khatib, Rasha
AU - Yusuf, Rita
AU - Boström, Kristina Bengtsson
AU - Zatonska, Katarzyna
AU - Iqbal, Romaina
AU - Weida, Liu
AU - Yibing, Zhu
AU - Sidong, Li
AU - Dans, Antonio
AU - Yusufali, Afzalhussein
AU - Mohammadifard, Noushin
AU - Marshall, John K.
AU - Moayyedi, Paul
AU - Reinisch, Walter
AU - Yusuf, Salim
N1 - Publisher Copyright:
© 2019 Author(s) (or their employer(s)).
PY - 2021/7/14
Y1 - 2021/7/14
N2 - Objective To evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD). Design Prospective cohort study. Setting 21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle East, south Asia, South East Asia, and China). Participants 116 087 adults aged 35-70 years with at least one cycle of follow-up and complete baseline food frequency questionnaire (FFQ) data (country specific validated FFQs were used to document baseline dietary intake). Participants were followed prospectively at least every three years. Main outcome measures The main outcome was development of IBD, including Crohn's disease or ulcerative colitis. Associations between ultra-processed food intake and risk of IBD were assessed using Cox proportional hazard multivariable models. Results are presented as hazard ratios with 95% confidence intervals. Results Participants were enrolled in the study between 2003 and 2016. During the median follow-up of 9.7 years (interquartile range 8.9-11.2 years), 467 participants developed incident IBD (90 with Crohn's disease and 377 with ulcerative colitis). After adjustment for potential confounding factors, higher intake of ultra-processed food was associated with a higher risk of incident IBD (hazard ratio 1.82, 95% confidence interval 1.22 to 2.72 for ≥5 servings/day and 1.67, 1.18 to 2.37 for 1-4 servings/day compared with <1 serving/day, P=0.006 for trend). Different subgroups of ultra-processed food, including soft drinks, refined sweetened foods, salty snacks, and processed meat, each were associated with higher hazard ratios for IBD. Results were consistent for Crohn's disease and ulcerative colitis with low heterogeneity. Intakes of white meat, red meat, dairy, starch, and fruit, vegetables, and legumes were not associated with incident IBD. Conclusions Higher intake of ultra-processed food was positively associated with risk of IBD. Further studies are needed to identify the contributory factors within ultra-processed foods.
AB - Objective To evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD). Design Prospective cohort study. Setting 21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle East, south Asia, South East Asia, and China). Participants 116 087 adults aged 35-70 years with at least one cycle of follow-up and complete baseline food frequency questionnaire (FFQ) data (country specific validated FFQs were used to document baseline dietary intake). Participants were followed prospectively at least every three years. Main outcome measures The main outcome was development of IBD, including Crohn's disease or ulcerative colitis. Associations between ultra-processed food intake and risk of IBD were assessed using Cox proportional hazard multivariable models. Results are presented as hazard ratios with 95% confidence intervals. Results Participants were enrolled in the study between 2003 and 2016. During the median follow-up of 9.7 years (interquartile range 8.9-11.2 years), 467 participants developed incident IBD (90 with Crohn's disease and 377 with ulcerative colitis). After adjustment for potential confounding factors, higher intake of ultra-processed food was associated with a higher risk of incident IBD (hazard ratio 1.82, 95% confidence interval 1.22 to 2.72 for ≥5 servings/day and 1.67, 1.18 to 2.37 for 1-4 servings/day compared with <1 serving/day, P=0.006 for trend). Different subgroups of ultra-processed food, including soft drinks, refined sweetened foods, salty snacks, and processed meat, each were associated with higher hazard ratios for IBD. Results were consistent for Crohn's disease and ulcerative colitis with low heterogeneity. Intakes of white meat, red meat, dairy, starch, and fruit, vegetables, and legumes were not associated with incident IBD. Conclusions Higher intake of ultra-processed food was positively associated with risk of IBD. Further studies are needed to identify the contributory factors within ultra-processed foods.
UR - http://www.scopus.com/inward/record.url?scp=85110702713&partnerID=8YFLogxK
U2 - 10.1136/bmj.n1554
DO - 10.1136/bmj.n1554
M3 - Artículo Científico
C2 - 34261638
AN - SCOPUS:85110702713
SN - 0959-8146
VL - 374
JO - British Medical Journal
JF - British Medical Journal
M1 - n1554
ER -