TY - JOUR
T1 - Association of dairy consumption with metabolic syndrome, hypertension and diabetes in 147 812 individuals from 21 countries
AU - Bhavadharini, Balaji
AU - Dehghan, Mahshid
AU - Mente, Andrew
AU - Rangarajan, Sumathy
AU - Sheridan, Patrick
AU - Mohan, Viswanathan
AU - Iqbal, Romaina
AU - Gupta, Rajeev
AU - Lear, Scott
AU - Wentzel-Viljoen, Edelweiss
AU - Avezum, Alvaro
AU - Lopez-Jaramillo, Patricio
AU - Mony, Prem
AU - Varma, Ravi Prasad
AU - Kumar, Rajesh
AU - Chifamba, Jephat
AU - Alhabib, Khalid F.
AU - Mohammadifard, Noushin
AU - Oguz, Aytekin
AU - Lanas, Fernando
AU - Rozanska, Dorota
AU - Bengtsson Bostrom, Kristina
AU - Yusoff, Khalid
AU - Tsolkile, Lungiswa P.
AU - Dans, Antonio
AU - Yusufali, Afzalhussein
AU - Orlandini, Andres
AU - Poirier, Paul
AU - Khatib, Rasha
AU - Hu, Bo
AU - Wei, Li
AU - Yin, Lu
AU - Deeraili, Ai
AU - Yeates, Karen
AU - Yusuf, Rita
AU - Ismail, Noorhassim
AU - Mozaffarian, Dariush
AU - Teo, Koon
AU - Anand, Sonia S.
AU - Yusuf, Salim
N1 - Publisher Copyright:
© © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2020/5/18
Y1 - 2020/5/18
N2 - Objective Our aims were to assess the association of dairy intake with prevalence of metabolic syndrome (MetS) (cross-sectionally) and with incident hypertension and incident diabetes (prospectively) in a large multinational cohort study. Methods The Prospective Urban Rural Epidemiology (PURE) study is a prospective epidemiological study of individuals aged 35 and 70 years from 21 countries on five continents, with a median follow-up of 9.1 years. In the cross-sectional analyses, we assessed the association of dairy intake with prevalent MetS and its components among individuals with information on the five MetS components (n=112 922). For the prospective analyses, we examined the association of dairy with incident hypertension (in 57 547 individuals free of hypertension) and diabetes (in 131 481 individuals free of diabetes). Results In cross-sectional analysis, higher intake of total dairy (at least two servings/day compared with zero intake; OR 0.76, 95% CI 0.71 to 0.80, p-trend<0.0001) was associated with a lower prevalence of MetS after multivariable adjustment. Higher intakes of whole fat dairy consumed alone (OR 0.72, 95% CI 0.66 to 0.78, p-trend<0.0001), or consumed jointly with low fat dairy (OR 0.89, 95% CI 0.80 to 0.98, p-trend=0.0005), were associated with a lower MetS prevalence. Low fat dairy consumed alone was not associated with MetS (OR 1.03, 95% CI 0.77 to 1.38, p-trend=0.13). In prospective analysis, 13 640 people with incident hypertension and 5351 people with incident diabetes were recorded. Higher intake of total dairy (at least two servings/day vs zero serving/day) was associated with a lower incidence of hypertension (HR 0.89, 95% CI 0.82 to 0.97, p-trend=0.02) and diabetes (HR 0.88, 95% CI 0.76 to 1.02, p-trend=0.01). Directionally similar associations were found for whole fat dairy versus each outcome. Conclusions Higher intake of whole fat (but not low fat) dairy was associated with a lower prevalence of MetS and most of its component factors, and with a lower incidence of hypertension and diabetes. Our findings should be evaluated in large randomized trials of the effects of whole fat dairy on the risks of MetS, hypertension, and diabetes.
AB - Objective Our aims were to assess the association of dairy intake with prevalence of metabolic syndrome (MetS) (cross-sectionally) and with incident hypertension and incident diabetes (prospectively) in a large multinational cohort study. Methods The Prospective Urban Rural Epidemiology (PURE) study is a prospective epidemiological study of individuals aged 35 and 70 years from 21 countries on five continents, with a median follow-up of 9.1 years. In the cross-sectional analyses, we assessed the association of dairy intake with prevalent MetS and its components among individuals with information on the five MetS components (n=112 922). For the prospective analyses, we examined the association of dairy with incident hypertension (in 57 547 individuals free of hypertension) and diabetes (in 131 481 individuals free of diabetes). Results In cross-sectional analysis, higher intake of total dairy (at least two servings/day compared with zero intake; OR 0.76, 95% CI 0.71 to 0.80, p-trend<0.0001) was associated with a lower prevalence of MetS after multivariable adjustment. Higher intakes of whole fat dairy consumed alone (OR 0.72, 95% CI 0.66 to 0.78, p-trend<0.0001), or consumed jointly with low fat dairy (OR 0.89, 95% CI 0.80 to 0.98, p-trend=0.0005), were associated with a lower MetS prevalence. Low fat dairy consumed alone was not associated with MetS (OR 1.03, 95% CI 0.77 to 1.38, p-trend=0.13). In prospective analysis, 13 640 people with incident hypertension and 5351 people with incident diabetes were recorded. Higher intake of total dairy (at least two servings/day vs zero serving/day) was associated with a lower incidence of hypertension (HR 0.89, 95% CI 0.82 to 0.97, p-trend=0.02) and diabetes (HR 0.88, 95% CI 0.76 to 1.02, p-trend=0.01). Directionally similar associations were found for whole fat dairy versus each outcome. Conclusions Higher intake of whole fat (but not low fat) dairy was associated with a lower prevalence of MetS and most of its component factors, and with a lower incidence of hypertension and diabetes. Our findings should be evaluated in large randomized trials of the effects of whole fat dairy on the risks of MetS, hypertension, and diabetes.
KW - adult diabetes
KW - endocrinology
KW - hypertension
KW - nutrition
UR - http://www.scopus.com/inward/record.url?scp=85084786808&partnerID=8YFLogxK
U2 - 10.1136/bmjdrc-2019-000826
DO - 10.1136/bmjdrc-2019-000826
M3 - Artículo Científico
C2 - 32423962
AN - SCOPUS:85084786808
SN - 2052-4897
VL - 8
JO - BMJ Open Diabetes Research and Care
JF - BMJ Open Diabetes Research and Care
IS - 1
M1 - e000826
ER -
