Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract

Alírica I. Suárez; Reinaldo S. Compagnone; Maria M. Salazar-Bookaman; Stephen Tillett; Franco Delle Monache; Camilo Di Giulio; Gustavo Bruges

doi:10.1016/S0378-8741(03)00179-X

Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract

Alírica I. Suárez, Reinaldo S. Compagnone, Maria M. Salazar-Bookaman, Stephen Tillett, Franco Delle Monache, Camilo Di Giulio, Gustavo Bruges

Research output: Articles / Notes › Scientific Article › peer-review

40 Scopus citations

Abstract

Croton malambo (K.) bark aqueous extract, popularly known in Venezuela as "palomatias" or "torco" was tested for acute toxicity and for its anti-inflammatory and antinociceptive effects using tail flick and writhing syndrome tests models, respectively. Croton malambo aqueous extract (6.15 mg/kg i.p.) administered intraperitoneally had a significant antinociceptive and anti-inflammatory effects compared to acetylsalicylic acid (200 mg/kg p.o.) and sodium diclofenac (5.64 mg/kg p.o.). Studies to determine correlation between chemical composition and pharmacological activity are underway.

Original language	English
Pages (from-to)	11-14
Number of pages	4
Journal	Journal of Ethnopharmacology
Volume	88
Issue number	1
DOIs	https://doi.org/10.1016/S0378-8741(03)00179-X
State	Published - 1 Sep 2003
Externally published	Yes

Keywords

Analgesic
Anti-inflammatory activity
Aqueous extract
Croton malambo

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10.1016/S0378-8741(03)00179-X

Cite this

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title = "Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract",

abstract = "Croton malambo (K.) bark aqueous extract, popularly known in Venezuela as {"}palomatias{"} or {"}torco{"} was tested for acute toxicity and for its anti-inflammatory and antinociceptive effects using tail flick and writhing syndrome tests models, respectively. Croton malambo aqueous extract (6.15 mg/kg i.p.) administered intraperitoneally had a significant antinociceptive and anti-inflammatory effects compared to acetylsalicylic acid (200 mg/kg p.o.) and sodium diclofenac (5.64 mg/kg p.o.). Studies to determine correlation between chemical composition and pharmacological activity are underway.",

keywords = "Analgesic, Anti-inflammatory activity, Aqueous extract, Croton malambo",

author = "Su{\'a}rez, {Al{\'i}rica I.} and Compagnone, {Reinaldo S.} and Salazar-Bookaman, {Maria M.} and Stephen Tillett and {Delle Monache}, Franco and {Di Giulio}, Camilo and Gustavo Bruges",

note = "Funding Information: Support for this research was provided in part by a grant from the Consejo de Desarrollo Cient{\'ı}fico y Humanistico de la UCV (Grant No. O6-30-4074-98), CYTED and FONACIT (Venezuela)—CNR (Italy) (Grant No. PI-2001000347). Special thanks to Dr. Antonio Su{\'a}rez, who made a great contribution to this research.",

year = "2003",

month = sep,

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doi = "10.1016/S0378-8741(03)00179-X",

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pages = "11--14",

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TY - JOUR

T1 - Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract

AU - Suárez, Alírica I.

AU - Compagnone, Reinaldo S.

AU - Salazar-Bookaman, Maria M.

AU - Tillett, Stephen

AU - Delle Monache, Franco

AU - Di Giulio, Camilo

AU - Bruges, Gustavo

N1 - Funding Information: Support for this research was provided in part by a grant from the Consejo de Desarrollo Cientı́fico y Humanistico de la UCV (Grant No. O6-30-4074-98), CYTED and FONACIT (Venezuela)—CNR (Italy) (Grant No. PI-2001000347). Special thanks to Dr. Antonio Suárez, who made a great contribution to this research.

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Croton malambo (K.) bark aqueous extract, popularly known in Venezuela as "palomatias" or "torco" was tested for acute toxicity and for its anti-inflammatory and antinociceptive effects using tail flick and writhing syndrome tests models, respectively. Croton malambo aqueous extract (6.15 mg/kg i.p.) administered intraperitoneally had a significant antinociceptive and anti-inflammatory effects compared to acetylsalicylic acid (200 mg/kg p.o.) and sodium diclofenac (5.64 mg/kg p.o.). Studies to determine correlation between chemical composition and pharmacological activity are underway.

AB - Croton malambo (K.) bark aqueous extract, popularly known in Venezuela as "palomatias" or "torco" was tested for acute toxicity and for its anti-inflammatory and antinociceptive effects using tail flick and writhing syndrome tests models, respectively. Croton malambo aqueous extract (6.15 mg/kg i.p.) administered intraperitoneally had a significant antinociceptive and anti-inflammatory effects compared to acetylsalicylic acid (200 mg/kg p.o.) and sodium diclofenac (5.64 mg/kg p.o.). Studies to determine correlation between chemical composition and pharmacological activity are underway.

KW - Analgesic

KW - Anti-inflammatory activity

KW - Aqueous extract

KW - Croton malambo

UR - http://www.scopus.com/inward/record.url?scp=0041666459&partnerID=8YFLogxK

U2 - 10.1016/S0378-8741(03)00179-X

DO - 10.1016/S0378-8741(03)00179-X

M3 - Artículo Científico

C2 - 12902046

AN - SCOPUS:0041666459

SN - 0378-8741

VL - 88

SP - 11

EP - 14

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

IS - 1

ER -

Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract

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Keywords

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