Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract

Alírica I. Suárez, Reinaldo S. Compagnone, Maria M. Salazar-Bookaman, Stephen Tillett, Franco Delle Monache, Camilo Di Giulio, Gustavo Bruges

Research output: Articles / NotesScientific Articlepeer-review

37 Scopus citations


Croton malambo (K.) bark aqueous extract, popularly known in Venezuela as "palomatias" or "torco" was tested for acute toxicity and for its anti-inflammatory and antinociceptive effects using tail flick and writhing syndrome tests models, respectively. Croton malambo aqueous extract (6.15 mg/kg i.p.) administered intraperitoneally had a significant antinociceptive and anti-inflammatory effects compared to acetylsalicylic acid (200 mg/kg p.o.) and sodium diclofenac (5.64 mg/kg p.o.). Studies to determine correlation between chemical composition and pharmacological activity are underway.

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalJournal of Ethnopharmacology
Issue number1
StatePublished - 1 Sep 2003
Externally publishedYes


  • Analgesic
  • Anti-inflammatory activity
  • Aqueous extract
  • Croton malambo


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